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- W2014889495 abstract "The aim of the present study was to investigate the effects of di(n-butyl)phthalate (DBP) on oxidative damage in the testes of hypothyroid rats. Hypothyroidism was induced by administering 0.1% 6-N-propyl-2-thiouracil (PTU) in drinking water for 30 days. DBP was dissolved in corn oil and administered daily for 30 days by oral gavage. Significant decreases in testes weight were observed both in normal (DBP) and hypothyroid (PTU + DBP) groups. Serum testosterone concentrations were significantly reduced in the DBP groups, but no significant change occurred in hypothyroid rats. Di(n-butyl)phthalate significantly increased malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG) level in the testes, whereas the DBP-induced oxidative lipid (MDA) and DNA (8-OHdG) damage were less in hypothyroid rats. PTU-induced hypothyroid rats decreased testicular catalase activity, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities did not show any significant changes. However, the DBP and PT..." @default.
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- W2014889495 date "2008-01-01" @default.
- W2014889495 modified "2023-09-27" @default.
- W2014889495 title "Alterations of di(n-butyl)phthalate-induced oxidative stress in the testis of hypothyroid rats" @default.
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- W2014889495 doi "https://doi.org/10.1080/02772240701284451" @default.
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