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• W2014889974 abstract "S-acetoin (S-AC) is an important four-carbon chiral compound that has unique industrial applications in the asymmetric synthesis of valuable chiral specialty chemicals. However, previous studies showed that the usually low yield and optical purity of S-AC as well as the very high substrate cost have hindered the application of this compound. In the current work, a gene encoding diacetyl reductase (DAR) from a Paenibacillus polymyxa strain ZJ-9 was cloned and expressed in Escherichia coli. Whole cells of the recombinant E. coli were used to produce S-AC from diacetyl (DA). Under optimal conditions, S-AC with high optical purity (purity >99·9%) was obtained with a yield of 13·5 ± 0·24 and 39·4 ± 0·38 g l(-1) under batch and fed-batch culture conditions, respectively. This process featured the biotransformation of DA into S-AC using whole cells of engineered E. coli. The result is a considerable increase in the yield and optical purity of S-AC, which in turn facilitated the practical application of the compound.This study demonstrated a highly efficient new method to produce S-acetoin with higher than 99·9% optical purity from diacetyl using whole cells of engineered Escherichia coli. It will therefore decrease the production cost of S-acetoin and highlight its application in asymmetric synthesis of highly valuable chiral compounds." @default.
• W2014889974 created "2016-06-24" @default.
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• W2014889974 date "2013-06-11" @default.
• W2014889974 modified "2023-09-28" @default.
• W2014889974 title "Production of <i>S</i> -acetoin from diacetyl by <i>Escherichia coli</i> transformant cells that express the diacetyl reductase gene of <i>Paenibacillus polymyxa </i> ZJ-9" @default.
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• W2014889974 doi "https://doi.org/10.1111/lam.12107" @default.
• W2014889974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23701367" @default.
• W2014889974 hasPublicationYear "2013" @default.
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