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• W2014890256 abstract "Abstract Cells derived from an epithelial‐mesenchymal transformation within the atrioventricular canal and outflow tract are involved in the partitioning of the early embryonic heart into a four‐chambered organ. This transformation process has been shown to proceed from an inductive interaction between the myocardium and competent, target endothelial cells within these regions of the heart. Interestingly, immunohistochemistry revealed the presence of fibronectinpositive particulates within the matrix of mesenchyme‐forming regions (Mjaatvedt et al., 1987). This particulate matrix is extractable by EDTA and can elicit the epithelial‐mesenchymal transformation in culture (Mjaatvedt and Markwald, 1989). Analysis of EDTA extracts of embryonic heart tissue revealed the presence of fibronectin and about 40 unidentified proteins, 6 of which appeared to be enriched in the biologically active 100,000g pellet fraction (Mjaatvedt and Markwald, 1989). Based on these and other data we have proposed that the particulate matrix is composed of a multicomponent complex of fibronectin and one or more of the low‐molecular‐weight proteins in this pellet. The purpose of the present study was to begin a biochemical characterization of the nonfibronectin proteins thought to be present in the matrix particulates. Given that many matrix constituents are glycoproteins, lectins were used to initially characterize the particulate constituents. Of the lectins tested, soybean agglutinin (SBA) was found to be specific only for matrix particulates. Histochemical analyses showed that SBA and antibodies against fibronectin colocalized regionally and temporally to the same matrix particulates in embryonic heart tissue. SBA‐agarose affinity chromatography resulted in the isolation of two major (56 and 69 kDa) and six minor (28, 46, 50, 53, 126, 220 kDa) proteins from EDTA extractable heart matrix. Temporal lectin histochemical studies indicate that SBA‐positive particulates are present in the matrix prior to mesenchyme formation, but are absent shortly after the transformation event. These observations support our hypothesis that one or more of these SBA‐positive glycoproteins participate in the endothelial‐mesenchymal transformation of cardiac endothelium." @default.
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• W2014890256 title "Multiple glycoproteins localize to a particulate form of extracellular matrix in regions of the embryonic heart where endothelial cells transform into mesenchyme" @default.
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• W2014890256 doi "https://doi.org/10.1002/ar.1092320213" @default.
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