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- W2014892095 abstract "Methylphenidate (0.3 mg/kg) was administered intravenously to 20 normal subjects. Behavioral responses varied considerably among individuals. Both cortisol and growth hormone showed significant increases (p < 0.001). The adrenocorticotrophic hormone (ACTH) response seemed insufficient to explain the increase in cortisol. For men only, the increase in cortisol correlated positively with the increase in epinephrine (r = 0.77, p < 0.05) and correlated negatively with baseline cortisol (r = −0.70, p < 0.05), with increase in growth hormone (r = −0.70, p < 0.05), and with the increase in “energy” (r = −0.83, p < 0.01). The growth hormone response varied between the sexes, and for men, the growth hormone correlated with both an increase in “energy” (r = 0.70, p < 0.05) and “friendliness” (r = 0.68, p < 0.05). For all subjects, baseline heart rate correlated with the increase in “energy” (r = −0.69, p < 0.002). In a separate study, six male subjects received, on different occasions, saline and a lower dose of methylphenidate. Together, these studies show that the increases in cortisol, growth hormone, and epinephrine, and the decrease in prolactin are dose-dependent." @default.
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- W2014892095 date "1986-09-01" @default.
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- W2014892095 title "Endocrine and behavioral responses to methylphenidate in normal subjects" @default.
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- W2014892095 doi "https://doi.org/10.1016/0006-3223(86)90282-9" @default.
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