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- W2014906225 abstract "Neonatal quinpirole (dopamine D2/D3 agonist) treatment to rats has been shown to increase dopamine D2 receptor sensitivity throughout the animal's lifetime. Male and female Sprague–Dawley rats were neonatalally treated with quinpirole (1 mg/kg) from postnatal days (P) 1–21 and raised to adulthood. Beginning on P62, rats were administered the atypical antipsychotic olanzapine (2.5 mg/kg) twice daily for 28 days. Starting 1 day after the end of olanzapine treatment, animals were behaviorally tested on the place and match-to-place version of the Morris water maze (MWM) over seven consecutive days, and a yawning behavioral test was also performed to test for sensitivity of the D2 receptor 1 day following MWM testing. Similar to results from a past study, olanzapine alleviated cognitive impairment on the MWM place version and increases in yawning produced by neonatal quinpirole treatment. Brain tissue analyses showed that neonatal quinpirole treatment resulted in a significant decrease of hipppocampal ChAT and BDNF RNA expression that were unaffected by adulthood olanzapine treatment, although adulthood olanzapine treatment produced a significant increase in cerebellar ChAT RNA expression. There were no significant effects of drug treatment on NGF RNA expression in any brain area. These results show that neonatal quinpirole treatment produced significant decreases of protein RNA expression that is specific to the hippocampus. Although olanzapine alleviated cognitive deficits produced by neonatal quinpirole treatment, it did not affect expression of proteins known to be important in cognitive performance." @default.
- W2014906225 created "2016-06-24" @default.
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- W2014906225 date "2008-03-01" @default.
- W2014906225 modified "2023-09-24" @default.
- W2014906225 title "Adulthood olanzapine treatment fails to alleviate decreases of ChAT and BDNF RNA expression in rats quinpirole-primed as neonates" @default.
- W2014906225 cites W1513894019 @default.
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- W2014906225 cites W1577577364 @default.
- W2014906225 cites W1818863325 @default.
- W2014906225 cites W1885182890 @default.
- W2014906225 cites W1963630844 @default.
- W2014906225 cites W1965232213 @default.
- W2014906225 cites W1967209958 @default.
- W2014906225 cites W1967314181 @default.
- W2014906225 cites W1967984696 @default.
- W2014906225 cites W1974098658 @default.
- W2014906225 cites W1974297775 @default.
- W2014906225 cites W1976622617 @default.
- W2014906225 cites W1977405586 @default.
- W2014906225 cites W1978018677 @default.
- W2014906225 cites W1979312944 @default.
- W2014906225 cites W1979466796 @default.
- W2014906225 cites W1981597687 @default.
- W2014906225 cites W1981870344 @default.
- W2014906225 cites W1985674713 @default.
- W2014906225 cites W1992991774 @default.
- W2014906225 cites W1993560189 @default.
- W2014906225 cites W1998669483 @default.
- W2014906225 cites W1999669481 @default.
- W2014906225 cites W1999926235 @default.
- W2014906225 cites W2000017647 @default.
- W2014906225 cites W2009052798 @default.
- W2014906225 cites W2012170779 @default.
- W2014906225 cites W2016389910 @default.
- W2014906225 cites W2017140635 @default.
- W2014906225 cites W2020218178 @default.
- W2014906225 cites W2020440721 @default.
- W2014906225 cites W2024489080 @default.
- W2014906225 cites W2025154046 @default.
- W2014906225 cites W2026785870 @default.
- W2014906225 cites W2026820525 @default.
- W2014906225 cites W2033555453 @default.
- W2014906225 cites W2042649817 @default.
- W2014906225 cites W2045198510 @default.
- W2014906225 cites W2045309216 @default.
- W2014906225 cites W2048360195 @default.
- W2014906225 cites W2048952435 @default.
- W2014906225 cites W2050386936 @default.
- W2014906225 cites W2051011222 @default.
- W2014906225 cites W2052719913 @default.
- W2014906225 cites W2054628630 @default.
- W2014906225 cites W2058034572 @default.
- W2014906225 cites W2063442676 @default.
- W2014906225 cites W2065027511 @default.
- W2014906225 cites W2065507332 @default.
- W2014906225 cites W2069316602 @default.
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- W2014906225 cites W2073442736 @default.
- W2014906225 cites W2085514510 @default.
- W2014906225 cites W2089147353 @default.
- W2014906225 cites W2093184684 @default.
- W2014906225 cites W2094902216 @default.
- W2014906225 cites W2099515172 @default.
- W2014906225 cites W2100646118 @default.
- W2014906225 cites W2101107458 @default.
- W2014906225 cites W2105012597 @default.
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- W2014906225 cites W2136614794 @default.
- W2014906225 cites W2136962131 @default.
- W2014906225 cites W2138101914 @default.
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- W2014906225 cites W2151331628 @default.
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- W2014906225 doi "https://doi.org/10.1016/j.brainres.2008.01.041" @default.
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