FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014906909> ?p ?o ?g. }

• W2014906909 endingPage "112" @default.
• W2014906909 startingPage "101" @default.
• W2014906909 abstract "Recent results from epidemiology, in vitro cell culture and in vivo (animal and human) studies have suggested the benefits of indole-3-carbinol (I3C) for the prevention of many types of cancer, including breast cancer. However, there are no reports, to the best of our knowledge, on the effect of I3C on isogenic nontumorigenic and tumorigenic breast epithelial cells, and there is a significant void in our understanding of the molecular mechanism(s) by which I3C induces apoptotic cell death in breast cancer cells. To fill this gap in our understanding, we conducted experiments to investigate the effects of I3C on an isogenic nontumorigenic (MCF10A) and tumorigenic (MCF10CA1a [CA1a]) breast epithelial cells. Here we show that CA1a cells are more sensitive to low concentration of I3C in terms of cell growth inhibition compared to MCF10A cells. We further report that I3C upregulates Bax/Bcl-2 ratio and downregulates Bcl-xL expression in CA1a cells but not in MCF10A cells. We also report, for the first time, that I3C induces Bax translocation to the mitochondria, causing mitochondrial depolarization, resulting in the loss of mitochondrial potential leading to the release of cytochrome c and subsequent cell death in CA1a cells but not in MCF10A cells. From these results, we conclude that I3C selectively induces apoptosis in breast cancer cells, but not in nontumorigenic breast epithelial cells, suggesting the potential therapeutic benefit of I3C against breast cancer." @default.
• W2014906909 created "2016-06-24" @default.
• W2014906909 creator A5004324298 @default.
• W2014906909 creator A5042547707 @default.
• W2014906909 creator A5044146501 @default.
• W2014906909 date "2003-01-01" @default.
• W2014906909 modified "2023-10-18" @default.
• W2014906909 title "Indole-3-Carbinol (I3C) Induces Apoptosis in Tumorigenic but Not in Nontumorigenic Breast Epithelial Cells" @default.
• W2014906909 cites W110134706 @default.
• W2014906909 cites W1972733192 @default.
• W2014906909 cites W1979805598 @default.
• W2014906909 cites W1986538794 @default.
• W2014906909 cites W1989040314 @default.
• W2014906909 cites W1993675387 @default.
• W2014906909 cites W1998891328 @default.
• W2014906909 cites W2008637375 @default.
• W2014906909 cites W2009792339 @default.
• W2014906909 cites W2018516136 @default.
• W2014906909 cites W2019572526 @default.
• W2014906909 cites W2025192458 @default.
• W2014906909 cites W2025458315 @default.
• W2014906909 cites W2032049833 @default.
• W2014906909 cites W2034621057 @default.
• W2014906909 cites W2038768123 @default.
• W2014906909 cites W2043153280 @default.
• W2014906909 cites W2044261960 @default.
• W2014906909 cites W2057713336 @default.
• W2014906909 cites W2058673968 @default.
• W2014906909 cites W2063176993 @default.
• W2014906909 cites W2070862399 @default.
• W2014906909 cites W2073028327 @default.
• W2014906909 cites W2076571195 @default.
• W2014906909 cites W2081145901 @default.
• W2014906909 cites W2085188839 @default.
• W2014906909 cites W2111213257 @default.
• W2014906909 cites W2117954572 @default.
• W2014906909 cites W2118397996 @default.
• W2014906909 cites W2126472654 @default.
• W2014906909 cites W2130866079 @default.
• W2014906909 cites W2134872883 @default.
• W2014906909 cites W2134979684 @default.
• W2014906909 cites W2135753091 @default.
• W2014906909 cites W2140967934 @default.
• W2014906909 cites W2163832837 @default.
• W2014906909 cites W2227165234 @default.
• W2014906909 cites W2320474741 @default.
• W2014906909 cites W2329475616 @default.
• W2014906909 cites W4245064765 @default.
• W2014906909 cites W4360754311 @default.
• W2014906909 doi "https://doi.org/10.1207/s15327914nc4501_12" @default.
• W2014906909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12791510" @default.
• W2014906909 hasPublicationYear "2003" @default.
• W2014906909 type Work @default.
• W2014906909 sameAs 2014906909 @default.
• W2014906909 citedByCount "78" @default.
• W2014906909 countsByYear W20149069092012 @default.
• W2014906909 countsByYear W20149069092013 @default.
• W2014906909 countsByYear W20149069092014 @default.
• W2014906909 countsByYear W20149069092015 @default.
• W2014906909 countsByYear W20149069092016 @default.
• W2014906909 countsByYear W20149069092017 @default.
• W2014906909 countsByYear W20149069092018 @default.
• W2014906909 countsByYear W20149069092019 @default.
• W2014906909 countsByYear W20149069092020 @default.
• W2014906909 countsByYear W20149069092021 @default.
• W2014906909 countsByYear W20149069092022 @default.
• W2014906909 countsByYear W20149069092023 @default.
• W2014906909 crossrefType "journal-article" @default.
• W2014906909 hasAuthorship W2014906909A5004324298 @default.
• W2014906909 hasAuthorship W2014906909A5042547707 @default.
• W2014906909 hasAuthorship W2014906909A5044146501 @default.
• W2014906909 hasConcept C121608353 @default.
• W2014906909 hasConcept C126322002 @default.
• W2014906909 hasConcept C190283241 @default.
• W2014906909 hasConcept C31573885 @default.
• W2014906909 hasConcept C502942594 @default.
• W2014906909 hasConcept C530470458 @default.
• W2014906909 hasConcept C54355233 @default.
• W2014906909 hasConcept C55493867 @default.
• W2014906909 hasConcept C71924100 @default.
• W2014906909 hasConcept C81885089 @default.
• W2014906909 hasConcept C86803240 @default.
• W2014906909 hasConcept C96232424 @default.
• W2014906909 hasConceptScore W2014906909C121608353 @default.
• W2014906909 hasConceptScore W2014906909C126322002 @default.
• W2014906909 hasConceptScore W2014906909C190283241 @default.
• W2014906909 hasConceptScore W2014906909C31573885 @default.
• W2014906909 hasConceptScore W2014906909C502942594 @default.
• W2014906909 hasConceptScore W2014906909C530470458 @default.
• W2014906909 hasConceptScore W2014906909C54355233 @default.
• W2014906909 hasConceptScore W2014906909C55493867 @default.
• W2014906909 hasConceptScore W2014906909C71924100 @default.
• W2014906909 hasConceptScore W2014906909C81885089 @default.
• W2014906909 hasConceptScore W2014906909C86803240 @default.
• W2014906909 hasConceptScore W2014906909C96232424 @default.
• W2014906909 hasIssue "1" @default.
• W2014906909 hasLocation W20149069091 @default.
• W2014906909 hasLocation W20149069092 @default.

• next