FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014909541> ?p ?o ?g. }

• W2014909541 endingPage "e81736" @default.
• W2014909541 startingPage "e81736" @default.
• W2014909541 abstract "Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo susceptibility, and expression of TNFB and ICAM1 affects the disease onset and progression. We have earlier reported the role of TNFA in autoimmune pathogenesis of vitiligo, and we now show the involvement of TNFB in vitiligo pathogenesis. The two polymorphisms investigated in the TNFB were in strong linkage disequilibrium and significantly associated with vitiligo. TNFB and ICAM1 transcripts were significantly increased in patients compared to controls. Active vitiligo patients showed significant increase in TNFB transcripts compared to stable vitiligo. The genotype-phenotype analysis revealed that TNFB expression levels were higher in patients with GG and AA genotypes as compared to controls. Patients with the early age of onset and female patients showed higher TNFB and ICAM1 expression. Overall, our findings suggest that the increased TNFB transcript levels in vitiligo patients could result, at least in part, from variations at the genetic level which in turn leads to increased ICAM1 expression. For the first time, we show that TNFB +252A/G and exon 3 C/A polymorphisms are associated with vitiligo susceptibility and influence the TNFB and ICAM1 expression. Moreover, the study also emphasizes influence of TNFB and ICAM1 on the disease progression, onset and gender bias for developing vitiligo." @default.
• W2014909541 created "2016-06-24" @default.
• W2014909541 creator A5007108973 @default.
• W2014909541 creator A5009930027 @default.
• W2014909541 creator A5026547797 @default.
• W2014909541 creator A5031066401 @default.
• W2014909541 creator A5090529387 @default.
• W2014909541 date "2013-11-27" @default.
• W2014909541 modified "2023-10-16" @default.
• W2014909541 title "Tumor Necrosis Factor B (TNFB) Genetic Variants and Its Increased Expression Are Associated with Vitiligo Susceptibility" @default.
• W2014909541 cites W1487018400 @default.
• W2014909541 cites W1553967198 @default.
• W2014909541 cites W1580883143 @default.
• W2014909541 cites W1603966665 @default.
• W2014909541 cites W1825259197 @default.
• W2014909541 cites W1952680786 @default.
• W2014909541 cites W1963500531 @default.
• W2014909541 cites W1963761177 @default.
• W2014909541 cites W1965538344 @default.
• W2014909541 cites W1968972058 @default.
• W2014909541 cites W1974845876 @default.
• W2014909541 cites W1978519490 @default.
• W2014909541 cites W1988199837 @default.
• W2014909541 cites W1991316437 @default.
• W2014909541 cites W1992256266 @default.
• W2014909541 cites W2000146955 @default.
• W2014909541 cites W2002507218 @default.
• W2014909541 cites W2010040020 @default.
• W2014909541 cites W2010753175 @default.
• W2014909541 cites W2011555335 @default.
• W2014909541 cites W2013426740 @default.
• W2014909541 cites W2016752509 @default.
• W2014909541 cites W2021064604 @default.
• W2014909541 cites W2022978891 @default.
• W2014909541 cites W2027416965 @default.
• W2014909541 cites W2032044021 @default.
• W2014909541 cites W2038467910 @default.
• W2014909541 cites W2038713790 @default.
• W2014909541 cites W2043909203 @default.
• W2014909541 cites W2045621229 @default.
• W2014909541 cites W2051166515 @default.
• W2014909541 cites W2051781518 @default.
• W2014909541 cites W2051867686 @default.
• W2014909541 cites W2052316493 @default.
• W2014909541 cites W2052702521 @default.
• W2014909541 cites W2061542205 @default.
• W2014909541 cites W2067118839 @default.
• W2014909541 cites W2067503899 @default.
• W2014909541 cites W2067893628 @default.
• W2014909541 cites W2069769149 @default.
• W2014909541 cites W2074730759 @default.
• W2014909541 cites W2075018325 @default.
• W2014909541 cites W2075119261 @default.
• W2014909541 cites W2076046713 @default.
• W2014909541 cites W2076840075 @default.
• W2014909541 cites W2076844852 @default.
• W2014909541 cites W2079655012 @default.
• W2014909541 cites W2082339884 @default.
• W2014909541 cites W2084604696 @default.
• W2014909541 cites W2085871829 @default.
• W2014909541 cites W2087484885 @default.
• W2014909541 cites W2088567444 @default.
• W2014909541 cites W2091048702 @default.
• W2014909541 cites W2092750918 @default.
• W2014909541 cites W2094227208 @default.
• W2014909541 cites W2094456933 @default.
• W2014909541 cites W2098000996 @default.
• W2014909541 cites W2098237519 @default.
• W2014909541 cites W2102488870 @default.
• W2014909541 cites W2109940257 @default.
• W2014909541 cites W2116293732 @default.
• W2014909541 cites W2116305767 @default.
• W2014909541 cites W2117147802 @default.
• W2014909541 cites W2119178580 @default.
• W2014909541 cites W2119662171 @default.
• W2014909541 cites W2119985510 @default.
• W2014909541 cites W2128573481 @default.
• W2014909541 cites W2135691584 @default.
• W2014909541 cites W2136250296 @default.
• W2014909541 cites W2138340454 @default.
• W2014909541 cites W2145033382 @default.
• W2014909541 cites W2150882333 @default.
• W2014909541 cites W2154579874 @default.
• W2014909541 cites W2156465884 @default.
• W2014909541 cites W2159222629 @default.
• W2014909541 cites W2162192283 @default.
• W2014909541 cites W2164851459 @default.
• W2014909541 cites W2176899369 @default.
• W2014909541 cites W2074576815 @default.
• W2014909541 doi "https://doi.org/10.1371/journal.pone.0081736" @default.
• W2014909541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842287" @default.
• W2014909541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24312346" @default.
• W2014909541 hasPublicationYear "2013" @default.
• W2014909541 type Work @default.
• W2014909541 sameAs 2014909541 @default.
• W2014909541 citedByCount "31" @default.
• W2014909541 countsByYear W20149095412014 @default.
• W2014909541 countsByYear W20149095412015 @default.

• next