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- W2014920245 abstract "Corticosteroid-induced osteoporosis is a major problem faced by rheumatologists, with up to 50% of patients at increased risk for vertebral fractures. Our current understanding of the pathophysiology of corticosteroid-induced osteoporosis suggests two basic problems: a reduction in bone formation and an increase in bone resorption leading to an overall reduction in bone mass. Adequate calcium and vitamin D intake, calcitonin, hormone-replacement therapy, and thiazide diuretics are of benefit in preventing corticosteroid-induced bone loss. Other therapies such as the bisphosphonates, fluoride, and anabolic steroids should be considered when fractures occur or ongoing bone loss is evident. A review of the literature outlining the pathophysiology, clinical features, assessment, and treatment is presented." @default.
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- W2014920245 date "1993-06-01" @default.
- W2014920245 modified "2023-10-17" @default.
- W2014920245 title "Corticosteroid-induced osteoporosis" @default.
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- W2014920245 doi "https://doi.org/10.1016/s0049-0172(05)80029-0" @default.
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