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- W2014920293 abstract "Abstract To verify whether the stimulation by sulpiride of hypothalamic adenylate cyclase was direct or mediated by release of pituitary hormones, the effect of sulpiride on female hypophysectomized rats was studied. In these animals sulpiride does not substantially modify hypothalamic adenylate cyclase, brain 3,4-dihydroxyphenylacetic acid (DOPAC) levels and serum prolactin concentrations. Chlorpromazine on the contrary inhibits hypothalamic adenylate cyclase activity and increases DOPAC levels both in intact and in hypophysectomized rats. As sulpiride hardly crosses the blood-brain barrier, its action on pituitary with prolactin release seems to be essential to start the neurochemical phenomena in the central nervous system." @default.
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- W2014920293 date "1978-12-01" @default.
- W2014920293 modified "2023-09-27" @default.
- W2014920293 title "Pituitary modulation of sulpiride action in the central nervous system of the rat" @default.
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- W2014920293 doi "https://doi.org/10.1016/0304-3940(78)90244-6" @default.
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