Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014927095> ?p ?o ?g. }
- W2014927095 endingPage "733" @default.
- W2014927095 startingPage "723" @default.
- W2014927095 abstract "The aryl hydrocarbon receptor (AHR) is a major transcription factor regulated by different mechanisms. The classical view of AHR activation by xenobiotics needs to be amended by recent findings on the regulation of AHR by endogenous ligands and by crosstalk with other signaling pathways. In the cytosol the AHR recruits a large number of binding partners, including HSP90, p23, XAP2 and the ubiquitin ligases cullin 4B and CHIP. Furthermore, XAP2 binds the cyclic nucleotide phosphodiesterases PDE2A and PDE4A5. PDE2A inhibits nuclear translocation of AHR suggesting an important regulatory role of cyclic nucleotides in AHR trafficking. Signaling involving cAMP is organized in subcellular compartments and a distinct cAMP compartment might be required for proper AHR mobility and function. We conclude that the AHR complex integrates ligand binding and cyclic nucleotide signaling to generate an adequate transcriptional response." @default.
- W2014927095 created "2016-06-24" @default.
- W2014927095 creator A5081220126 @default.
- W2014927095 creator A5089913118 @default.
- W2014927095 date "2009-02-01" @default.
- W2014927095 modified "2023-10-15" @default.
- W2014927095 title "Phosphodiesterases link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling" @default.
- W2014927095 cites W1505278126 @default.
- W2014927095 cites W1511208409 @default.
- W2014927095 cites W1519040062 @default.
- W2014927095 cites W1558386025 @default.
- W2014927095 cites W1574770390 @default.
- W2014927095 cites W1595835172 @default.
- W2014927095 cites W1675449053 @default.
- W2014927095 cites W1935479846 @default.
- W2014927095 cites W1964453982 @default.
- W2014927095 cites W1969120382 @default.
- W2014927095 cites W1969529910 @default.
- W2014927095 cites W1973902556 @default.
- W2014927095 cites W1974621567 @default.
- W2014927095 cites W1974833672 @default.
- W2014927095 cites W1975619716 @default.
- W2014927095 cites W1976846448 @default.
- W2014927095 cites W1982395222 @default.
- W2014927095 cites W1986321253 @default.
- W2014927095 cites W1988229163 @default.
- W2014927095 cites W1997568999 @default.
- W2014927095 cites W1999964339 @default.
- W2014927095 cites W2004177921 @default.
- W2014927095 cites W2005585150 @default.
- W2014927095 cites W2006579483 @default.
- W2014927095 cites W2007232482 @default.
- W2014927095 cites W2009917029 @default.
- W2014927095 cites W2018058179 @default.
- W2014927095 cites W2022156064 @default.
- W2014927095 cites W2022713347 @default.
- W2014927095 cites W2025639825 @default.
- W2014927095 cites W2027704011 @default.
- W2014927095 cites W2029656987 @default.
- W2014927095 cites W2032217767 @default.
- W2014927095 cites W2033883932 @default.
- W2014927095 cites W2036804729 @default.
- W2014927095 cites W2036845348 @default.
- W2014927095 cites W2038186997 @default.
- W2014927095 cites W2041792760 @default.
- W2014927095 cites W2045374621 @default.
- W2014927095 cites W2049631853 @default.
- W2014927095 cites W2049970818 @default.
- W2014927095 cites W2050572437 @default.
- W2014927095 cites W2052701304 @default.
- W2014927095 cites W2053578835 @default.
- W2014927095 cites W2054316167 @default.
- W2014927095 cites W2054524070 @default.
- W2014927095 cites W2054562330 @default.
- W2014927095 cites W2055073146 @default.
- W2014927095 cites W2057201113 @default.
- W2014927095 cites W2062818823 @default.
- W2014927095 cites W2063716341 @default.
- W2014927095 cites W2064579697 @default.
- W2014927095 cites W2066254714 @default.
- W2014927095 cites W2067627058 @default.
- W2014927095 cites W2072786589 @default.
- W2014927095 cites W2073430420 @default.
- W2014927095 cites W2075763186 @default.
- W2014927095 cites W2081410156 @default.
- W2014927095 cites W2085729235 @default.
- W2014927095 cites W2086212720 @default.
- W2014927095 cites W2087632584 @default.
- W2014927095 cites W2091726431 @default.
- W2014927095 cites W2096666806 @default.
- W2014927095 cites W2099846796 @default.
- W2014927095 cites W2100193266 @default.
- W2014927095 cites W2101071262 @default.
- W2014927095 cites W2102880335 @default.
- W2014927095 cites W2104479866 @default.
- W2014927095 cites W2107607858 @default.
- W2014927095 cites W2107945943 @default.
- W2014927095 cites W2108837396 @default.
- W2014927095 cites W2111325313 @default.
- W2014927095 cites W2115277334 @default.
- W2014927095 cites W2115347995 @default.
- W2014927095 cites W2123465466 @default.
- W2014927095 cites W2128583496 @default.
- W2014927095 cites W2129026083 @default.
- W2014927095 cites W2131330272 @default.
- W2014927095 cites W2133363610 @default.
- W2014927095 cites W2133972226 @default.
- W2014927095 cites W2138913971 @default.
- W2014927095 cites W2141306531 @default.
- W2014927095 cites W2141738832 @default.
- W2014927095 cites W2146909058 @default.
- W2014927095 cites W2147812298 @default.
- W2014927095 cites W2149540498 @default.
- W2014927095 cites W2149871191 @default.
- W2014927095 cites W2150047915 @default.
- W2014927095 cites W2150070004 @default.
- W2014927095 cites W2153495469 @default.
- W2014927095 cites W2155149275 @default.