Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014927480> ?p ?o ?g. }
- W2014927480 endingPage "534" @default.
- W2014927480 startingPage "527" @default.
- W2014927480 abstract "miRNAs (microRNAs) play important roles in diverse physiological processes, including stress response, apoptosis and carcinogenesis. Even though the role of individual miRNAs has been demonstrated, expression of proteins involved in miRNA production in response to acute stress or harmful agents has not been extensively investigated. Here, we have studied the role of Dicer, one of the central proteins of the miRNA processing machinery during apoptosis, and show that down-regulation of Dicer results in accelerated apoptosis of HeLa cells, triggered by TNFalpha (tumour necrosis factor alpha). We have also investigated the integrity of Dicer, and provide evidence that Dicer is a target for caspases during apoptosis. The cleavage of Dicer is stimulidependent and more pronounced when apoptosis is induced by PKC (protein kinase C) inhibitors, and can also be observed in HIV-1-infected cells at late stages of infection. Thus the apoptotic machinery may regulate the miRNA pathway by affecting individual proteins, such as Dicer." @default.
- W2014927480 created "2016-06-24" @default.
- W2014927480 creator A5009542962 @default.
- W2014927480 creator A5049872530 @default.
- W2014927480 date "2008-05-28" @default.
- W2014927480 modified "2023-10-08" @default.
- W2014927480 title "Stimuli-dependent cleavage of Dicer during apoptosis" @default.
- W2014927480 cites W180867511 @default.
- W2014927480 cites W1829961297 @default.
- W2014927480 cites W1968427910 @default.
- W2014927480 cites W1976077409 @default.
- W2014927480 cites W1980269624 @default.
- W2014927480 cites W1992935306 @default.
- W2014927480 cites W2001605136 @default.
- W2014927480 cites W2014138744 @default.
- W2014927480 cites W2019739870 @default.
- W2014927480 cites W2026403124 @default.
- W2014927480 cites W2033469771 @default.
- W2014927480 cites W2040708394 @default.
- W2014927480 cites W2044945534 @default.
- W2014927480 cites W2054109341 @default.
- W2014927480 cites W2061210125 @default.
- W2014927480 cites W2062465863 @default.
- W2014927480 cites W2066173314 @default.
- W2014927480 cites W2069855944 @default.
- W2014927480 cites W207029473 @default.
- W2014927480 cites W2071562706 @default.
- W2014927480 cites W2072680951 @default.
- W2014927480 cites W2076398093 @default.
- W2014927480 cites W2079472722 @default.
- W2014927480 cites W2086227770 @default.
- W2014927480 cites W2096152713 @default.
- W2014927480 cites W2098472306 @default.
- W2014927480 cites W2112785261 @default.
- W2014927480 cites W2117991391 @default.
- W2014927480 cites W2118105142 @default.
- W2014927480 cites W2118364944 @default.
- W2014927480 cites W2119015197 @default.
- W2014927480 cites W2123285970 @default.
- W2014927480 cites W2130863312 @default.
- W2014927480 cites W2137130773 @default.
- W2014927480 cites W2140601448 @default.
- W2014927480 cites W2149127266 @default.
- W2014927480 cites W2165310182 @default.
- W2014927480 cites W2165836180 @default.
- W2014927480 cites W2168106981 @default.
- W2014927480 cites W4255771281 @default.
- W2014927480 doi "https://doi.org/10.1042/bj20071461" @default.
- W2014927480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18289125" @default.
- W2014927480 hasPublicationYear "2008" @default.
- W2014927480 type Work @default.
- W2014927480 sameAs 2014927480 @default.
- W2014927480 citedByCount "39" @default.
- W2014927480 countsByYear W20149274802012 @default.
- W2014927480 countsByYear W20149274802013 @default.
- W2014927480 countsByYear W20149274802015 @default.
- W2014927480 countsByYear W20149274802017 @default.
- W2014927480 countsByYear W20149274802018 @default.
- W2014927480 countsByYear W20149274802019 @default.
- W2014927480 countsByYear W20149274802020 @default.
- W2014927480 countsByYear W20149274802021 @default.
- W2014927480 countsByYear W20149274802022 @default.
- W2014927480 countsByYear W20149274802023 @default.
- W2014927480 crossrefType "journal-article" @default.
- W2014927480 hasAuthorship W2014927480A5009542962 @default.
- W2014927480 hasAuthorship W2014927480A5049872530 @default.
- W2014927480 hasConcept C104317684 @default.
- W2014927480 hasConcept C145059251 @default.
- W2014927480 hasConcept C151730666 @default.
- W2014927480 hasConcept C166703698 @default.
- W2014927480 hasConcept C175156509 @default.
- W2014927480 hasConcept C190283241 @default.
- W2014927480 hasConcept C2777366897 @default.
- W2014927480 hasConcept C2779867133 @default.
- W2014927480 hasConcept C2780096491 @default.
- W2014927480 hasConcept C31573885 @default.
- W2014927480 hasConcept C43369102 @default.
- W2014927480 hasConcept C54355233 @default.
- W2014927480 hasConcept C67705224 @default.
- W2014927480 hasConcept C78604142 @default.
- W2014927480 hasConcept C81885089 @default.
- W2014927480 hasConcept C86803240 @default.
- W2014927480 hasConcept C95444343 @default.
- W2014927480 hasConcept C98424977 @default.
- W2014927480 hasConceptScore W2014927480C104317684 @default.
- W2014927480 hasConceptScore W2014927480C145059251 @default.
- W2014927480 hasConceptScore W2014927480C151730666 @default.
- W2014927480 hasConceptScore W2014927480C166703698 @default.
- W2014927480 hasConceptScore W2014927480C175156509 @default.
- W2014927480 hasConceptScore W2014927480C190283241 @default.
- W2014927480 hasConceptScore W2014927480C2777366897 @default.
- W2014927480 hasConceptScore W2014927480C2779867133 @default.
- W2014927480 hasConceptScore W2014927480C2780096491 @default.
- W2014927480 hasConceptScore W2014927480C31573885 @default.
- W2014927480 hasConceptScore W2014927480C43369102 @default.
- W2014927480 hasConceptScore W2014927480C54355233 @default.
- W2014927480 hasConceptScore W2014927480C67705224 @default.
- W2014927480 hasConceptScore W2014927480C78604142 @default.