FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014933196> ?p ?o ?g. }

• W2014933196 endingPage "451" @default.
• W2014933196 startingPage "439" @default.
• W2014933196 abstract "We have investigated whether Ca 2+ entry through T‐type Ca 2+ channels participates in triggering Ca 2+ release from the sarcoplasmic reticulum (SR) in single guinea‐pig ventricular myocytes (whole‐cell voltage clamp, K 5 fura‐2 as [Ca 2+ ] i indicator; all monovalent cations replaced by impermeant ions to record uncontaminated Ca 2+ currents; T = 23 or 36 °C). T‐type Ca 2+ currents were elicited from a holding potential of ‐90 mV during steps to ‐50 to ‐20 mV. For steps to ‐50 mV, very small [Ca 2+ ] i transients could be recorded with high loading of the SR (peak Δ[Ca 2+ ] i , 67 ± 41 nM; n = 9 ). For steps to ‐40, ‐30 and ‐20 mV, we compared the amplitude of Ca 2+ release for a holding potential of ‐50 mV with L‐type Ca 2+ current only to Ca 2+ release for a holding potential of ‐90 mV with both T‐ and L‐type Ca 2+ current. Significantly more Ca 2+ release was observed with T‐type current present, and both the T‐type current and the additional Ca 2+ release were suppressed by 50 μM NiCl 2 . Ca 2+ influx through T‐type Ca 2+ channels triggered less Ca 2+ release than a comparable Ca 2+ influx through L‐type Ca 2+ channels. Rapid block of T‐type Ca 2+ current during the action potential (50 μM NiCl 2 during steady‐state stimulation at 1 or 2 Hz) did not immediately reduce Ca 2+ release, although a small decrease was observed after longer application. We conclude that T‐type Ca 2+ current can trigger Ca 2+ release from the SR albeit less efficiently than L‐type Ca 2+ current. T‐type current is most likely to provide only a small contribution to the trigger for Ca 2+ release in normal conditions. These results support the hypothesis that L‐type Ca 2+ channels have a privileged role in excitation‐contraction coupling." @default.
• W2014933196 created "2016-06-24" @default.
• W2014933196 creator A5042788376 @default.
• W2014933196 creator A5051925167 @default.
• W2014933196 creator A5070495078 @default.
• W2014933196 date "1998-04-01" @default.
• W2014933196 modified "2023-10-15" @default.
• W2014933196 title "T-type Ca²⁺current as a trigger for Ca²⁺release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes" @default.
• W2014933196 cites W118659659 @default.
• W2014933196 cites W1872391952 @default.
• W2014933196 cites W1969894123 @default.
• W2014933196 cites W1974015977 @default.
• W2014933196 cites W1978867040 @default.
• W2014933196 cites W1983128983 @default.
• W2014933196 cites W1987416588 @default.
• W2014933196 cites W1998299402 @default.
• W2014933196 cites W2003784210 @default.
• W2014933196 cites W2004403903 @default.
• W2014933196 cites W2012659747 @default.
• W2014933196 cites W2021647551 @default.
• W2014933196 cites W2022759249 @default.
• W2014933196 cites W2028575503 @default.
• W2014933196 cites W2034877370 @default.
• W2014933196 cites W2037842047 @default.
• W2014933196 cites W2055984902 @default.
• W2014933196 cites W2062157267 @default.
• W2014933196 cites W2064351258 @default.
• W2014933196 cites W2066953355 @default.
• W2014933196 cites W2069230499 @default.
• W2014933196 cites W2070441180 @default.
• W2014933196 cites W2075172074 @default.
• W2014933196 cites W2075544896 @default.
• W2014933196 cites W2081090062 @default.
• W2014933196 cites W2082982910 @default.
• W2014933196 cites W2092067715 @default.
• W2014933196 cites W2092643356 @default.
• W2014933196 cites W2102878096 @default.
• W2014933196 cites W2104640347 @default.
• W2014933196 cites W2112583647 @default.
• W2014933196 cites W2134064208 @default.
• W2014933196 cites W2142226883 @default.
• W2014933196 cites W2153194642 @default.
• W2014933196 cites W2154446983 @default.
• W2014933196 cites W2163958661 @default.
• W2014933196 cites W2397817760 @default.
• W2014933196 cites W2411321078 @default.
• W2014933196 cites W4239219601 @default.
• W2014933196 doi "https://doi.org/10.1111/j.1469-7793.1998.439bq.x" @default.
• W2014933196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2230898" @default.
• W2014933196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9508808" @default.
• W2014933196 hasPublicationYear "1998" @default.
• W2014933196 type Work @default.
• W2014933196 sameAs 2014933196 @default.
• W2014933196 citedByCount "117" @default.
• W2014933196 countsByYear W20149331962012 @default.
• W2014933196 countsByYear W20149331962013 @default.
• W2014933196 countsByYear W20149331962014 @default.
• W2014933196 countsByYear W20149331962015 @default.
• W2014933196 countsByYear W20149331962016 @default.
• W2014933196 countsByYear W20149331962018 @default.
• W2014933196 countsByYear W20149331962019 @default.
• W2014933196 countsByYear W20149331962020 @default.
• W2014933196 countsByYear W20149331962021 @default.
• W2014933196 countsByYear W20149331962022 @default.
• W2014933196 crossrefType "journal-article" @default.
• W2014933196 hasAuthorship W2014933196A5042788376 @default.
• W2014933196 hasAuthorship W2014933196A5051925167 @default.
• W2014933196 hasAuthorship W2014933196A5070495078 @default.
• W2014933196 hasBestOaLocation W20149331961 @default.
• W2014933196 hasConcept C113196181 @default.
• W2014933196 hasConcept C12554922 @default.
• W2014933196 hasConcept C134018914 @default.
• W2014933196 hasConcept C158617107 @default.
• W2014933196 hasConcept C178790620 @default.
• W2014933196 hasConcept C185592680 @default.
• W2014933196 hasConcept C18699975 @default.
• W2014933196 hasConcept C207200792 @default.
• W2014933196 hasConcept C24998067 @default.
• W2014933196 hasConcept C43617362 @default.
• W2014933196 hasConcept C519063684 @default.
• W2014933196 hasConcept C55493867 @default.
• W2014933196 hasConcept C86803240 @default.
• W2014933196 hasConceptScore W2014933196C113196181 @default.
• W2014933196 hasConceptScore W2014933196C12554922 @default.
• W2014933196 hasConceptScore W2014933196C134018914 @default.
• W2014933196 hasConceptScore W2014933196C158617107 @default.
• W2014933196 hasConceptScore W2014933196C178790620 @default.
• W2014933196 hasConceptScore W2014933196C185592680 @default.
• W2014933196 hasConceptScore W2014933196C18699975 @default.
• W2014933196 hasConceptScore W2014933196C207200792 @default.
• W2014933196 hasConceptScore W2014933196C24998067 @default.
• W2014933196 hasConceptScore W2014933196C43617362 @default.
• W2014933196 hasConceptScore W2014933196C519063684 @default.
• W2014933196 hasConceptScore W2014933196C55493867 @default.
• W2014933196 hasConceptScore W2014933196C86803240 @default.
• W2014933196 hasIssue "2" @default.
• W2014933196 hasLocation W20149331961 @default.
• W2014933196 hasLocation W20149331962 @default.

• next