Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014939186> ?p ?o ?g. }
- W2014939186 abstract "The objective of the present study was to evaluate the protective effects of halofuginone against renal ischemia/reperfusion (I/R) injury.Male Wistar albino rats were unilaterally nephrectomized and the left renal pedicles were occluded for 45 min to induce ischemia and then reperfused for 6 h (early) or for 72 h (late). The rats were treated intraperitoneally with either halofuginone (100 μg/kg/day) or saline 30 min prior to ischemia and the dose was repeated in the late reperfusion groups. In the sham groups, rats underwent unilateral nephrectomy and were treated at similar time points. The animals were decapitated at either 6 h or 72 h of reperfusion and trunk blood and kidney samples were obtained.I/R injury increased renal malondialdehyde levels, myeloperoxidase activity and reactive oxygen radical levels, and decreased the renal glutathione content. Halofuginone treatment was found to reduce oxidative I/R injury and improve renal function in the rat kidney, as evidenced by reduced generation of reactive oxygen species, depressed lipid peroxidation and myeloperoxidase activity, and increased glutathione levels.The present findings demonstrate the anti-inflammatory and antioxidant effects of halofuginone in renal I/R injury, supporting its potential use where renal I/R injury is inevitable." @default.
- W2014939186 created "2016-06-24" @default.
- W2014939186 creator A5002912590 @default.
- W2014939186 creator A5009088727 @default.
- W2014939186 creator A5010573674 @default.
- W2014939186 creator A5037496153 @default.
- W2014939186 creator A5050361522 @default.
- W2014939186 creator A5059324792 @default.
- W2014939186 creator A5075367601 @default.
- W2014939186 creator A5090894601 @default.
- W2014939186 date "2013-04-01" @default.
- W2014939186 modified "2023-10-12" @default.
- W2014939186 title "The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats" @default.
- W2014939186 cites W1559734295 @default.
- W2014939186 cites W1590457525 @default.
- W2014939186 cites W1786911182 @default.
- W2014939186 cites W1891967301 @default.
- W2014939186 cites W1967353947 @default.
- W2014939186 cites W1969651661 @default.
- W2014939186 cites W1975730872 @default.
- W2014939186 cites W1976312773 @default.
- W2014939186 cites W1978505738 @default.
- W2014939186 cites W1980699998 @default.
- W2014939186 cites W1981897563 @default.
- W2014939186 cites W1985980869 @default.
- W2014939186 cites W1989868286 @default.
- W2014939186 cites W1990206356 @default.
- W2014939186 cites W1992857831 @default.
- W2014939186 cites W1995086133 @default.
- W2014939186 cites W1997787506 @default.
- W2014939186 cites W1998005490 @default.
- W2014939186 cites W2001776741 @default.
- W2014939186 cites W2003063024 @default.
- W2014939186 cites W2003813474 @default.
- W2014939186 cites W2008044944 @default.
- W2014939186 cites W2014929896 @default.
- W2014939186 cites W2017134039 @default.
- W2014939186 cites W2020358486 @default.
- W2014939186 cites W2027779322 @default.
- W2014939186 cites W2032381326 @default.
- W2014939186 cites W2032550419 @default.
- W2014939186 cites W2042171658 @default.
- W2014939186 cites W2048221993 @default.
- W2014939186 cites W2049741850 @default.
- W2014939186 cites W2055515365 @default.
- W2014939186 cites W2059846555 @default.
- W2014939186 cites W2060332263 @default.
- W2014939186 cites W2068335228 @default.
- W2014939186 cites W2073653948 @default.
- W2014939186 cites W2073938229 @default.
- W2014939186 cites W2079854377 @default.
- W2014939186 cites W2081773805 @default.
- W2014939186 cites W2085440450 @default.
- W2014939186 cites W2086398892 @default.
- W2014939186 cites W2089221443 @default.
- W2014939186 cites W2092835460 @default.
- W2014939186 cites W2096068924 @default.
- W2014939186 cites W2112695637 @default.
- W2014939186 cites W2122869582 @default.
- W2014939186 cites W2133432809 @default.
- W2014939186 cites W2133485412 @default.
- W2014939186 cites W2134363454 @default.
- W2014939186 cites W2135633069 @default.
- W2014939186 cites W2137646911 @default.
- W2014939186 cites W2143597881 @default.
- W2014939186 cites W2144789534 @default.
- W2014939186 cites W2148282755 @default.
- W2014939186 cites W2152981283 @default.
- W2014939186 cites W2153419053 @default.
- W2014939186 cites W2164437042 @default.
- W2014939186 cites W2166174547 @default.
- W2014939186 cites W2187449277 @default.
- W2014939186 cites W2468858310 @default.
- W2014939186 cites W2562769361 @default.
- W2014939186 cites W2980011754 @default.
- W2014939186 cites W3123142171 @default.
- W2014939186 cites W31745767 @default.
- W2014939186 doi "https://doi.org/10.1016/j.jpurol.2012.01.015" @default.
- W2014939186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22373656" @default.
- W2014939186 hasPublicationYear "2013" @default.
- W2014939186 type Work @default.
- W2014939186 sameAs 2014939186 @default.
- W2014939186 citedByCount "5" @default.
- W2014939186 countsByYear W20149391862013 @default.
- W2014939186 countsByYear W20149391862017 @default.
- W2014939186 countsByYear W20149391862019 @default.
- W2014939186 crossrefType "journal-article" @default.
- W2014939186 hasAuthorship W2014939186A5002912590 @default.
- W2014939186 hasAuthorship W2014939186A5009088727 @default.
- W2014939186 hasAuthorship W2014939186A5010573674 @default.
- W2014939186 hasAuthorship W2014939186A5037496153 @default.
- W2014939186 hasAuthorship W2014939186A5050361522 @default.
- W2014939186 hasAuthorship W2014939186A5059324792 @default.
- W2014939186 hasAuthorship W2014939186A5075367601 @default.
- W2014939186 hasAuthorship W2014939186A5090894601 @default.
- W2014939186 hasConcept C126322002 @default.
- W2014939186 hasConcept C126894567 @default.
- W2014939186 hasConcept C134018914 @default.
- W2014939186 hasConcept C159641895 @default.
- W2014939186 hasConcept C203565725 @default.