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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014942004> ?p ?o ?g. }

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• W2014942004 abstract "Methylglyoxal (MGO) is a cytotoxic metabolite produced by in-vivo glycolysis that may result in diabetic complications. The aim of this study was to determine whether MGO and oxidative stress caused apoptosis of renal podocytes in the Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes mellitus. Male ZDF rats aged 21 weeks developed marked hyperglycaemia with proteinuria and albuminuria. Immunohistochemical evaluation of sections of kidney demonstrated expression of MGO and 8-hydroxydeoxyguanosine (8-OHdG) in the podocytes of both normoglycaemic and diabetic rats. Podocyte apoptosis was shown through application of the TUNEL method. These findings suggest that expression of MGO and 8-OHdG is caused by hyperglycaemia, and that this expression is associated with the observed apoptosis of podocytes and is related to diabetic nephropathy." @default.
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• W2014942004 date "2011-01-01" @default.
• W2014942004 modified "2023-10-04" @default.
• W2014942004 title "Renal Podocyte Apoptosis in Zucker Diabetic Fatty Rats: Involvement of Methylglyoxal-Induced Oxidative DNA Damage" @default.
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• W2014942004 doi "https://doi.org/10.1016/j.jcpa.2010.04.008" @default.
• W2014942004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20541219" @default.
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