FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014947250> ?p ?o ?g. }

• W2014947250 endingPage "11" @default.
• W2014947250 startingPage "11" @default.
• W2014947250 abstract "Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study Miwa Kawanaka,1 Ken Nishino,1 Jun Nakamura,1 Mitsuhiko Suehiro,1 Daisuke Goto,1 Noriyo Urata,1 Takahito Oka,1 Hirofumi Kawamoto,1 Hajime Nakamura,2 Junji Yodoi,3 Keisuke Hino,4 Gotaro Yamada11Department of Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School, Okayama, 2Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, 3Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, 4Department of Hepatology and Pancreatology, Kawasaki Medical School, Okayama, JapanBackground: Nonalcoholic steatohepatitis (NASH) is a common liver disease that can progress to cirrhosis. Oxidative stress is one of the central mechanisms causing hepatocellular injury in the disease. In this study, antioxidant therapy using both vitamins C and E was conducted in patients with NASH.Methods: Vitamin E 300 mg/day and vitamin C 300 mg/day were administered orally to 23 patients with NASH for 12 months. Body mass index was measured during therapy. Serum levels of alanine aminotransferase, thioredoxin (an oxidative stress marker), and high-sensitivity C-reactive protein were measured before treatment and after 12 months in all patients. Ten of the 23 patients underwent liver biopsy before and after treatment.Results: Body mass index remained unchanged during treatment with vitamins C and E. Serum alanine aminotransferase, thioredoxin, and high-sensitivity C-reactive protein levels were decreased significantly at 12 months compared with pretreatment. Liver biopsies showed improved necroinflammatory activity in eight cases and improved fibrosis staging in 4.Conclusion: Serum alanine aminotransferase, thioredoxin, and high-sensitivity C-reactive protein levels, and liver histology were clearly improved with vitamin C and E therapy. These findings suggest that combination therapy using these vitamins may be useful in patients with NASH to minimize damage from oxidative stress and slow the processes leading to cirrhosis.Keywords: vitamin E, vitamin C, nonalcoholic steatohepatitis, oxidative stress" @default.
• W2014947250 created "2016-06-24" @default.
• W2014947250 creator A5016064473 @default.
• W2014947250 creator A5016294535 @default.
• W2014947250 creator A5023301990 @default.
• W2014947250 creator A5025371497 @default.
• W2014947250 creator A5035428231 @default.
• W2014947250 creator A5036591947 @default.
• W2014947250 creator A5047567639 @default.
• W2014947250 creator A5053294093 @default.
• W2014947250 creator A5054134672 @default.
• W2014947250 creator A5072364978 @default.
• W2014947250 creator A5081252831 @default.
• W2014947250 creator A5085951307 @default.
• W2014947250 date "2013-03-01" @default.
• W2014947250 modified "2023-09-30" @default.
• W2014947250 title "Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study" @default.
• W2014947250 cites W1968396962 @default.
• W2014947250 cites W1982145118 @default.
• W2014947250 cites W1982578021 @default.
• W2014947250 cites W1983417944 @default.
• W2014947250 cites W1988981256 @default.
• W2014947250 cites W1989620365 @default.
• W2014947250 cites W1992691583 @default.
• W2014947250 cites W2002502142 @default.
• W2014947250 cites W2003403665 @default.
• W2014947250 cites W2046360039 @default.
• W2014947250 cites W2062812115 @default.
• W2014947250 cites W2069553469 @default.
• W2014947250 cites W2069726649 @default.
• W2014947250 cites W2082299629 @default.
• W2014947250 cites W2087829753 @default.
• W2014947250 cites W2128543587 @default.
• W2014947250 cites W2142844314 @default.
• W2014947250 cites W2144178804 @default.
• W2014947250 cites W2164039603 @default.
• W2014947250 cites W2314673390 @default.
• W2014947250 doi "https://doi.org/10.2147/hmer.s41258" @default.
• W2014947250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3953734" @default.
• W2014947250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24695939" @default.
• W2014947250 hasPublicationYear "2013" @default.
• W2014947250 type Work @default.
• W2014947250 sameAs 2014947250 @default.
• W2014947250 citedByCount "18" @default.
• W2014947250 countsByYear W20149472502014 @default.
• W2014947250 countsByYear W20149472502015 @default.
• W2014947250 countsByYear W20149472502016 @default.
• W2014947250 countsByYear W20149472502017 @default.
• W2014947250 countsByYear W20149472502018 @default.
• W2014947250 countsByYear W20149472502020 @default.
• W2014947250 countsByYear W20149472502021 @default.
• W2014947250 countsByYear W20149472502022 @default.
• W2014947250 countsByYear W20149472502023 @default.
• W2014947250 crossrefType "journal-article" @default.
• W2014947250 hasAuthorship W2014947250A5016064473 @default.
• W2014947250 hasAuthorship W2014947250A5016294535 @default.
• W2014947250 hasAuthorship W2014947250A5023301990 @default.
• W2014947250 hasAuthorship W2014947250A5025371497 @default.
• W2014947250 hasAuthorship W2014947250A5035428231 @default.
• W2014947250 hasAuthorship W2014947250A5036591947 @default.
• W2014947250 hasAuthorship W2014947250A5047567639 @default.
• W2014947250 hasAuthorship W2014947250A5053294093 @default.
• W2014947250 hasAuthorship W2014947250A5054134672 @default.
• W2014947250 hasAuthorship W2014947250A5072364978 @default.
• W2014947250 hasAuthorship W2014947250A5081252831 @default.
• W2014947250 hasAuthorship W2014947250A5085951307 @default.
• W2014947250 hasBestOaLocation W20149472501 @default.
• W2014947250 hasConcept C126322002 @default.
• W2014947250 hasConcept C134018914 @default.
• W2014947250 hasConcept C203014093 @default.
• W2014947250 hasConcept C2522874641 @default.
• W2014947250 hasConcept C2775934546 @default.
• W2014947250 hasConcept C2776151105 @default.
• W2014947250 hasConcept C2776408679 @default.
• W2014947250 hasConcept C2776954865 @default.
• W2014947250 hasConcept C2777075537 @default.
• W2014947250 hasConcept C2777214474 @default.
• W2014947250 hasConcept C2777551382 @default.
• W2014947250 hasConcept C2777766500 @default.
• W2014947250 hasConcept C2778004101 @default.
• W2014947250 hasConcept C2778772119 @default.
• W2014947250 hasConcept C2779134260 @default.
• W2014947250 hasConcept C2779478299 @default.
• W2014947250 hasConcept C2780022331 @default.
• W2014947250 hasConcept C2780040827 @default.
• W2014947250 hasConcept C41260117 @default.
• W2014947250 hasConcept C55493867 @default.
• W2014947250 hasConcept C71924100 @default.
• W2014947250 hasConcept C86803240 @default.
• W2014947250 hasConcept C90924648 @default.
• W2014947250 hasConceptScore W2014947250C126322002 @default.
• W2014947250 hasConceptScore W2014947250C134018914 @default.
• W2014947250 hasConceptScore W2014947250C203014093 @default.
• W2014947250 hasConceptScore W2014947250C2522874641 @default.
• W2014947250 hasConceptScore W2014947250C2775934546 @default.
• W2014947250 hasConceptScore W2014947250C2776151105 @default.
• W2014947250 hasConceptScore W2014947250C2776408679 @default.
• W2014947250 hasConceptScore W2014947250C2776954865 @default.

• next