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- W2014953991 abstract "In a previous article,<sup>1</sup>a description was given of the process by which blood macrophages inoculated in vitro with filtered extract of Rous sarcoma become transformed into malignant cells. The comparison of the normal and malignant strains showed that the sarcomatous monocyte is a diseased cell which is short lived, digests fibrin rapidly, transforms itself readily into fibroblasts, and reproduces the Rous principle. During this process, the culture assumes the appearance of a geographic map or moth-eaten cloth. It reminds one of the clear areas that Twort observed developing in his cultures of micrococcus after he had inoculated them with the lytic principle, called later bacteriophage by d'Herelle. In those areas, the micrococci underwent lysis and regenerated the lytic principle, and the phenomenon could repeat itself indefinitely. In an analogous manner, the macrophages inoculated with filtered sarcoma reproduce the Rous substance and die. The malignant element of the tumor is" @default.
- W2014953991 created "2016-06-24" @default.
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- W2014953991 date "1925-06-13" @default.
- W2014953991 modified "2023-09-24" @default.
- W2014953991 title "THE MECHANISM OF THE FORMATION OF SARCOMA" @default.
- W2014953991 cites W2082763301 @default.
- W2014953991 doi "https://doi.org/10.1001/jama.1925.02660500003002" @default.
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