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• W2014955142 abstract "The myelin basic protein (MBP) gene encodes two families of proteins: the classic MBP constituents of myelin and the golli-MBPs, the function of which is less well understood. Previous work suggests that golli proteins may play a role in Ca 2+ homeostasis in oligodendrocytes (OLs) and in T-cells. Overexpression of golli in OL cell lines induces elaboration of sheets and processes. Live imaging of these cells revealed a rapid retraction of the processes and sheets after depolarization with high K + . This phenomenon was associated with a significant increase in [Ca 2+ ] int without changes in cell viability. The results indicated that golli produced its effect through Ca 2+ influx, rather than Ca 2+ release from intracellular stores. Furthermore, a specific [Ca 2+ ] int chelator (BAPTA) or Cd 2+ , a specific blocker of voltage-operated Ca 2+ channels, abolished the ability of golli to promote process extension in a dose-dependent manner. Analysis of the golli protein identified a myristoylation site at the C terminus of the golli domain, which was essential for the action of golli on Ca 2+ influx, suggesting that binding of golli to the plasma membrane is important for modulating Ca 2+ homeostasis. High-resolution spatiotemporal analysis along N19 processes revealed higher-amplitude local Ca 2+ influx in regions with elevated levels of golli. These findings suggest a key role for golli proteins in regulating voltage-gated Ca 2+ channels in OLs during process remodeling. Our observations are consistent with the hypothesis that golli proteins, as a part of a protein complex, modulate Ca 2+ influx at the plasma membrane and along OL processes." @default.
• W2014955142 created "2016-06-24" @default.
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• W2014955142 date "2007-11-14" @default.
• W2014955142 modified "2023-10-14" @default.
• W2014955142 title "Increased Expression of Golli Myelin Basic Proteins Enhances Calcium Influx into Oligodendroglial Cells" @default.
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• W2014955142 doi "https://doi.org/10.1523/jneurosci.2381-07.2007" @default.
• W2014955142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673339" @default.
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