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• W2014958698 abstract "Objective This study aims to assess whether the timing of menopausal hormone therapy initiation in relation to onset of menopause and hormone therapy duration is associated with myocardial infarction risk. Methods This study was based on the Stockholm Heart Epidemiology Program, a population-based case-control study including 347 postmenopausal women who had experienced a nonfatal myocardial infarction and 499 female control individuals matched for age and residential area. Odds ratios (with 95% CIs) for myocardial infarction were calculated using logistic regression. Results Early initiation of hormone therapy (within 10 y of onset of menopause or before age 60 y), compared with never use, was associated with an odds ratio of 0.87 (95% CI, 0.58-1.30) after adjustments for lifestyle factors, body mass index, and socioeconomic status. For late initiation of hormone therapy, the corresponding odds ratio was 0.97 (95% CI, 0.53-1.76). For hormone therapy duration of 5 years or more, compared with never use, the adjusted odds ratio was 0.64 (95% CI, 0.35-1.18). For hormone therapy duration of less than 5 years, the odds ratio was 0.97 (95% CI, 0.63-1.48). Conclusions Neither the timing of hormone therapy initiation nor the duration of therapy is significantly associated with myocardial infarction risk." @default.
• W2014958698 created "2016-06-24" @default.
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• W2014958698 date "2015-06-01" @default.
• W2014958698 modified "2023-10-11" @default.
• W2014958698 title "Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? A population-based case-control study" @default.
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• W2014958698 doi "https://doi.org/10.1097/gme.0000000000000354" @default.
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