FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014961034> ?p ?o ?g. }

• W2014961034 endingPage "2364" @default.
• W2014961034 startingPage "2356" @default.
• W2014961034 abstract "Cancer-associated fibroblasts (CAFs), the most abundant and probably the most active cellular component of breast cancer-associated stroma, promote carcinogenesis through paracrine effects; however, the molecular basis remains elusive. We have shown here that p16(INK4A) expression is reduced in 83% CAFs as compared with their normal adjacent counterparts cancer-free tissues isolated from the same patients. This decrease is mainly due to AUF1-dependent higher turnover of the CDKN2A mRNA in CAFs. Importantly, p16(INK4A) downregulation using specific siRNA activated breast fibroblasts and increased the expression/secretion levels of stromal cell-derived factor 1 (SDF-1) and matrix metalloproteinase (MMP)-2. Consequently, media conditioned with these cells stimulated the proliferation of epithelial cells. Furthermore, the migration/invasion of breast cancer cells was also enhanced in an SDF-1-dependent manner. This effect was mediated through inducing an epithelial-mesenchymal transition state. By contrast, increase in p16(INK4A) level through ectopic expression or AUF1 downregulation, reduced the secreted levels of SDF-1 and MMP-2 and suppressed the pro-carcinogenic effects of CAFs. In addition, p16(INK4A)-defective fibroblasts accelerated breast tumor xenograft formation and growth rate in mice. Importantly, tumors formed in the presence of p16(INK4A)-defective fibroblasts exhibited higher levels of active Akt, Cox-2, MMP-2 and MMP-9, showing their greater aggressiveness as compared with xenografts formed in the presence of p16(INK4A)-proficient fibroblasts. These results provide the first indication that p16(INK4A) downregulation in breast stromal fibroblasts is an important step toward their activation." @default.
• W2014961034 created "2016-06-24" @default.
• W2014961034 creator A5028398390 @default.
• W2014961034 creator A5038471270 @default.
• W2014961034 creator A5044355502 @default.
• W2014961034 creator A5082727407 @default.
• W2014961034 date "2012-07-02" @default.
• W2014961034 modified "2023-10-14" @default.
• W2014961034 title "p16INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts" @default.
• W2014961034 cites W1964306359 @default.
• W2014961034 cites W1968291309 @default.
• W2014961034 cites W1971140306 @default.
• W2014961034 cites W1980750965 @default.
• W2014961034 cites W1993410462 @default.
• W2014961034 cites W1996118868 @default.
• W2014961034 cites W2007366900 @default.
• W2014961034 cites W2007617551 @default.
• W2014961034 cites W2016838970 @default.
• W2014961034 cites W2017235640 @default.
• W2014961034 cites W2019517928 @default.
• W2014961034 cites W2027322279 @default.
• W2014961034 cites W2029712941 @default.
• W2014961034 cites W2030905560 @default.
• W2014961034 cites W2033347017 @default.
• W2014961034 cites W2036680234 @default.
• W2014961034 cites W2038996871 @default.
• W2014961034 cites W2049820772 @default.
• W2014961034 cites W2054823277 @default.
• W2014961034 cites W2062809449 @default.
• W2014961034 cites W2066503677 @default.
• W2014961034 cites W2066848701 @default.
• W2014961034 cites W2070852249 @default.
• W2014961034 cites W2080225687 @default.
• W2014961034 cites W2086294121 @default.
• W2014961034 cites W2086772583 @default.
• W2014961034 cites W2087837666 @default.
• W2014961034 cites W2096241632 @default.
• W2014961034 cites W2101037339 @default.
• W2014961034 cites W2106787323 @default.
• W2014961034 cites W2107542925 @default.
• W2014961034 cites W2110237197 @default.
• W2014961034 cites W2111342463 @default.
• W2014961034 cites W2116904882 @default.
• W2014961034 cites W2135981246 @default.
• W2014961034 cites W2137459844 @default.
• W2014961034 cites W2160219683 @default.
• W2014961034 cites W2160938780 @default.
• W2014961034 cites W2164451932 @default.
• W2014961034 cites W2168002648 @default.
• W2014961034 cites W2168649860 @default.
• W2014961034 doi "https://doi.org/10.1038/onc.2012.270" @default.
• W2014961034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3898112" @default.
• W2014961034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22751126" @default.
• W2014961034 hasPublicationYear "2012" @default.
• W2014961034 type Work @default.
• W2014961034 sameAs 2014961034 @default.
• W2014961034 citedByCount "64" @default.
• W2014961034 countsByYear W20149610342012 @default.
• W2014961034 countsByYear W20149610342013 @default.
• W2014961034 countsByYear W20149610342014 @default.
• W2014961034 countsByYear W20149610342015 @default.
• W2014961034 countsByYear W20149610342016 @default.
• W2014961034 countsByYear W20149610342017 @default.
• W2014961034 countsByYear W20149610342018 @default.
• W2014961034 countsByYear W20149610342019 @default.
• W2014961034 countsByYear W20149610342020 @default.
• W2014961034 countsByYear W20149610342021 @default.
• W2014961034 countsByYear W20149610342022 @default.
• W2014961034 countsByYear W20149610342023 @default.
• W2014961034 crossrefType "journal-article" @default.
• W2014961034 hasAuthorship W2014961034A5028398390 @default.
• W2014961034 hasAuthorship W2014961034A5038471270 @default.
• W2014961034 hasAuthorship W2014961034A5044355502 @default.
• W2014961034 hasAuthorship W2014961034A5082727407 @default.
• W2014961034 hasBestOaLocation W20149610341 @default.
• W2014961034 hasConcept C104317684 @default.
• W2014961034 hasConcept C121608353 @default.
• W2014961034 hasConcept C127561419 @default.
• W2014961034 hasConcept C16930146 @default.
• W2014961034 hasConcept C170493617 @default.
• W2014961034 hasConcept C2776107976 @default.
• W2014961034 hasConcept C2909706936 @default.
• W2014961034 hasConcept C3020616263 @default.
• W2014961034 hasConcept C502942594 @default.
• W2014961034 hasConcept C54355233 @default.
• W2014961034 hasConcept C55493867 @default.
• W2014961034 hasConcept C555283112 @default.
• W2014961034 hasConcept C7876069 @default.
• W2014961034 hasConcept C86803240 @default.
• W2014961034 hasConceptScore W2014961034C104317684 @default.
• W2014961034 hasConceptScore W2014961034C121608353 @default.
• W2014961034 hasConceptScore W2014961034C127561419 @default.
• W2014961034 hasConceptScore W2014961034C16930146 @default.
• W2014961034 hasConceptScore W2014961034C170493617 @default.
• W2014961034 hasConceptScore W2014961034C2776107976 @default.
• W2014961034 hasConceptScore W2014961034C2909706936 @default.
• W2014961034 hasConceptScore W2014961034C3020616263 @default.
• W2014961034 hasConceptScore W2014961034C502942594 @default.

• next