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- W2014980411 abstract "The chemotactic response of eosinophils from 16 patients with atopic dermatitis (AD) to 5 eosinophil chemotactic factors (ECFs) were examined to clarify whether the response is associated with the clinical severity of AD. The factors included ECF-PI5, -PI6, -PI7, -PI8 and -PI9 and were derived from a T cell line, STO-2. The patients were divided into 2 groups according to the percentage migration of eosinophils produced by the ECFs: a high-responding group (migration > 40%), and a low-responding group (migration < 30%). In a statistical analysis, eosinophils from patients with AD and atopic respiratory diseases (ARD) were found to be high-responding and those from patients with AD alone low-responding (p < 0.01). In a comparison of the chemotactic response of eosinophils from patients with AD alone at remission and at exacerbation, the percentage migrations in response to ECF-PI5 and ECF-PI6 at exacerbation were significantly higher than that at remission (p < 0.05). It is thus suggested that this type of heterogeneous response of eosinophils to STO-2-derived ECFs could provide a useful tool for evaluation of disease severity in patients with AD." @default.
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- W2014980411 title "Heterogeneous Chemotactic Response of Eosinophils from Patients with Atopic Dermatitis to Eosinophil Chemotactic Factors" @default.
- W2014980411 doi "https://doi.org/10.1159/000237409" @default.
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