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- W2014984471 abstract "A method using capillary electrophoresis-mass spectrometry (CE-MS) was developed for the structural elucidation of bupivacaine and metabolites in rat urine. Prior to CE-MS analysis, solid-phase extraction (SPE) was used for sample cleanup and preconcentration purposes. Exact mass and tandem mass spectrometric (MS/MS) experiments were performed to obtain structural information about the unknown metabolites. Two instruments with different mass analyzers were used for mass spectrometric detection. A quadrupole time-of-flight (Q-TOF) and a magnetic sector hybrid instrument were coupled to CE and used for the analysis of urine extracts. Hydroxybupivacaine as well as five other isomerically different metabolites were detected including methoxylated bupivacaine." @default.
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- W2014984471 date "2003-07-01" @default.
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- W2014984471 title "Determination of bupivacaine and metabolites in rat urine using capillary electrophoresis with mass spectrometric detection" @default.
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- W2014984471 doi "https://doi.org/10.1002/elps.200305469" @default.
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