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- W2014991431 abstract "Preterm birth is the main cause of adverse perinatal outcome in the western world. Randomized controlled trials of nifedipine maintenance tocolysis in patients with threatened preterm labor have shown no clear benefit on perinatal outcome and contradicting results of prolongation of pregnancy. Our objective was to combine different randomized trials in an individual patient data meta-analysis to evaluate the effect of maintenance tocolysis on perinatal outcome. We performed an individual participant data meta-analysis of randomized trials on nifedipine maintenance tocolysis. We searched for studies on pregnant patients between 24 and 34 weeks of gestation with threatened preterm labor who had not delivered after tocolysis for 48 hours. We added the data of the individual trials in one dataset. Primary outcome was adverse perinatal outcome, defined as a composite of perinatal death, infant respiratory distress syndrome, necrotizing enterocolitis and intraventricular hemorrhage > grade 2. Secondary outcomes included gestational age at delivery and prolongation of pregnancy. We identified 3 double-blind, placebo-controlled trials, that included 522 patients with 638 children, of which 254 patients had been allocated to nifedipine and 268 to placebo. Baseline characteristics in both groups were comparable. Adverse perinatal outcome was not significantly different between the two groups: 13.4 % in the nifedipine group and 12.6 % in the placebo group (RR 1.0; 95% CI 0.65–1.7). Gestational age at delivery was comparable for both groups;. median prolongation of pregnancy was 31 (10.3–57) and 36 (9.8–60) days in the nifedipine and placebo group, respectively (HR 0.98; 95% CI 0.83–1.2). Mean length of neonatal intensive care unit admission was comparable. After successful tocolysis in patients with threatened preterm labor, maintenance tocolysis is ineffective in reducing adverse perinatal outcome and in prolonging pregnancy." @default.
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- W2014991431 date "2013-01-01" @default.
- W2014991431 modified "2023-09-25" @default.
- W2014991431 title "502: Is maintenance tocolysis with nifedipine effective in the reduction of adverse perinatal outcome: an individual participant data meta-analysis" @default.
- W2014991431 doi "https://doi.org/10.1016/j.ajog.2012.10.668" @default.
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