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• W2014992810 abstract "Pirlindole, a racemic antidepressant drug, was recently resolved using the derivatization method coupled with preparative HPLC. In order to improve this technique, the use of amino acid derivatives as chiral derivatizing agents (CDA) was investigated. Among different residues, the (L)-phenylalanine methyl ester was found to be very effective to separate pirlindole enantiomers using a medium pressure liquid chromatographic (MPLC) method. This procedure is better adapted to preparative application than HPLC. Thus, several grams of the pirlindole antipodes were isolated and characterized. These two enantiomers permitted the study of the stereochemical influence at the pharmacological level. Chirality 11:261–266, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2014992810 date "1999-01-01" @default.
• W2014992810 modified "2023-10-08" @default.
• W2014992810 title "Effective resolution of racemic pirlindole at the preparative scale" @default.
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• W2014992810 doi "https://doi.org/10.1002/(sici)1520-636x(1999)11:4<261::aid-chir1>3.0.co;2-s" @default.
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