FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014992854> ?p ?o ?g. }

• W2014992854 abstract "Recently, it was demonstrated that endogenous relaxin promotes growth of the vagina during the second half of pregnancy in rats and that administration of porcine relaxin promotes growth of the uterus in nonpregnant or early pregnant gilts. This study examined the effects of circulating relaxin on growth of both the vagina and uterus during the last two thirds of the 114-day gestation period in gilts. Furthermore, this study employed an in vitro immunohistochemical localization technique to determine whether the vagina and uterus in pigs have specific relaxin-binding sites. Three groups of pregnant gilts were used: sham-ovariectomized controls (group C; n = 8), ovariectomized progesterone-treated (group OP; n = 6), and ovariectomized progesterone- plus relaxin-treated (group OPR; n = 7). Gilts were either sham ovariectomized or ovariectomized on day 40 of gestation. Hormone replacement therapy with progesterone (group OP), progesterone plus relaxin (group OPR), or hormone vehicles (group C) began on day 38 (progesterone) or day 40 (relaxin) and continued until day 110. On day 110, the vagina and uterus were collected, and wet weight, dry weight, and percent hydration were determined. Small pieces (2-3 cm3) of the vagina and uterus from groups C and OP were frozen and cryosectioned for the immunohistochemical localization of relaxin-binding sites. Relaxin promoted growth of both the vagina and uterus. The wet weights of both the vagina and uterus in relaxin-deficient gilts (group OP) were lower (P < 0.05) than those in controls (group C), and relaxin replacement therapy (group OPR) restored the wet weights of both tissues to values that did not differ from those in controls. The mean dry weights and percent hydrations in the vagina and uterus did not differ among treatments. Immunohistochemical localization studies in the vagina and uterus demonstrated that specific and saturable binding of relaxin was localized in the same cell types of both tissues, namely epithelial cells (luminal in vagina, and both luminal and glandular in uterus), smooth muscle cells (both circular and longitudinal in vagina, and myometrial in uterus), and cells associated with blood vessels. In conclusion, this study provides evidence that circulating relaxin promotes growth of both the vagina and uterus during pregnancy in the pig. Furthermore, this study provides evidence that both the vagina and uterus contain specific and saturable relaxin-binding sites in epithelial cells, smooth muscle cells, and cells associated with blood vessels. We conclude that these cells probably initiate relaxin's effects on the vagina and uterus of the pregnant pig." @default.
• W2014992854 created "2016-06-24" @default.
• W2014992854 creator A5036629320 @default.
• W2014992854 creator A5047041792 @default.
• W2014992854 creator A5060130555 @default.
• W2014992854 creator A5072106047 @default.
• W2014992854 creator A5080507586 @default.
• W2014992854 date "1997-02-01" @default.
• W2014992854 modified "2023-10-16" @default.
• W2014992854 title "Evidence That Endogenous Relaxin Promotes Growth of the Vagina and Uterus during Pregnancy in Gilts1" @default.
• W2014992854 cites W18081750 @default.
• W2014992854 cites W1977963688 @default.
• W2014992854 cites W1978487089 @default.
• W2014992854 cites W1978850525 @default.
• W2014992854 cites W1980483493 @default.
• W2014992854 cites W1984467148 @default.
• W2014992854 cites W1987862017 @default.
• W2014992854 cites W1995265819 @default.
• W2014992854 cites W2005857816 @default.
• W2014992854 cites W2011449661 @default.
• W2014992854 cites W2018140866 @default.
• W2014992854 cites W2026143845 @default.
• W2014992854 cites W2027238617 @default.
• W2014992854 cites W2029937182 @default.
• W2014992854 cites W2040699655 @default.
• W2014992854 cites W2044034401 @default.
• W2014992854 cites W2048725598 @default.
• W2014992854 cites W2058953115 @default.
• W2014992854 cites W2059415978 @default.
• W2014992854 cites W2059633205 @default.
• W2014992854 cites W2071979007 @default.
• W2014992854 cites W2085865284 @default.
• W2014992854 cites W2097147102 @default.
• W2014992854 cites W2097430813 @default.
• W2014992854 cites W2119231737 @default.
• W2014992854 cites W2121568163 @default.
• W2014992854 cites W2158631792 @default.
• W2014992854 cites W2160570399 @default.
• W2014992854 cites W2165635177 @default.
• W2014992854 cites W2169911329 @default.
• W2014992854 cites W2097237179 @default.
• W2014992854 cites W2416220565 @default.
• W2014992854 doi "https://doi.org/10.1210/endo.138.2.4909" @default.
• W2014992854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9002986" @default.
• W2014992854 hasPublicationYear "1997" @default.
• W2014992854 type Work @default.
• W2014992854 sameAs 2014992854 @default.
• W2014992854 citedByCount "28" @default.
• W2014992854 countsByYear W20149928542013 @default.
• W2014992854 countsByYear W20149928542016 @default.
• W2014992854 countsByYear W20149928542019 @default.
• W2014992854 countsByYear W20149928542020 @default.
• W2014992854 crossrefType "journal-article" @default.
• W2014992854 hasAuthorship W2014992854A5036629320 @default.
• W2014992854 hasAuthorship W2014992854A5047041792 @default.
• W2014992854 hasAuthorship W2014992854A5060130555 @default.
• W2014992854 hasAuthorship W2014992854A5072106047 @default.
• W2014992854 hasAuthorship W2014992854A5080507586 @default.
• W2014992854 hasBestOaLocation W20149928541 @default.
• W2014992854 hasConcept C105702510 @default.
• W2014992854 hasConcept C126322002 @default.
• W2014992854 hasConcept C134018914 @default.
• W2014992854 hasConcept C172680121 @default.
• W2014992854 hasConcept C201614185 @default.
• W2014992854 hasConcept C2777121736 @default.
• W2014992854 hasConcept C2777744392 @default.
• W2014992854 hasConcept C2779066055 @default.
• W2014992854 hasConcept C2779234561 @default.
• W2014992854 hasConcept C46973012 @default.
• W2014992854 hasConcept C54355233 @default.
• W2014992854 hasConcept C71315377 @default.
• W2014992854 hasConcept C71924100 @default.
• W2014992854 hasConcept C8264082 @default.
• W2014992854 hasConcept C86803240 @default.
• W2014992854 hasConceptScore W2014992854C105702510 @default.
• W2014992854 hasConceptScore W2014992854C126322002 @default.
• W2014992854 hasConceptScore W2014992854C134018914 @default.
• W2014992854 hasConceptScore W2014992854C172680121 @default.
• W2014992854 hasConceptScore W2014992854C201614185 @default.
• W2014992854 hasConceptScore W2014992854C2777121736 @default.
• W2014992854 hasConceptScore W2014992854C2777744392 @default.
• W2014992854 hasConceptScore W2014992854C2779066055 @default.
• W2014992854 hasConceptScore W2014992854C2779234561 @default.
• W2014992854 hasConceptScore W2014992854C46973012 @default.
• W2014992854 hasConceptScore W2014992854C54355233 @default.
• W2014992854 hasConceptScore W2014992854C71315377 @default.
• W2014992854 hasConceptScore W2014992854C71924100 @default.
• W2014992854 hasConceptScore W2014992854C8264082 @default.
• W2014992854 hasConceptScore W2014992854C86803240 @default.
• W2014992854 hasLocation W20149928541 @default.
• W2014992854 hasLocation W20149928542 @default.
• W2014992854 hasOpenAccess W2014992854 @default.
• W2014992854 hasPrimaryLocation W20149928541 @default.
• W2014992854 hasRelatedWork W171909971 @default.
• W2014992854 hasRelatedWork W1966895214 @default.
• W2014992854 hasRelatedWork W2014992854 @default.
• W2014992854 hasRelatedWork W2052559628 @default.
• W2014992854 hasRelatedWork W2058364977 @default.
• W2014992854 hasRelatedWork W2073613265 @default.
• W2014992854 hasRelatedWork W2076313893 @default.

• next