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• W2014993624 abstract "Therapy targeted against the epidermal growth factor receptor (EGFR) has demonstrated dramatic tumor responses and favorable clinical outcomes in a select group of non-small cell lung cancer (NSCLC) patients whose tumors harbor EGFR activating mutations. The best characterized of the mutations conferring sensitivity to EGFR tyrosine kinase inhibitors (TKIs) are deletions in exon 19 and a point mutation in exon 21 (L858R). Likewise, the most common mutation that confers resistance is the T790M point mutation. However several other mutations have been reported and several have been characterized as regards their role in sensitivity or resistance to EGFR TKIs. Resistance to the EGFR TKIs erlotinib and gefitinib, and the newer irreversible EGFR TKIs is a problem of fundamental importance. Recognition of the presence and significance of specific EGFR mutations is important for appropriate therapeutic implementation of EGFR TKIs and research and development of mutation-specific inhibitors. We summarize the literature and present an overview of the subject of less common EGFR mutations and their clinical significance, with an emphasis on EGFR TKI sensitivity or resistance." @default.
• W2014993624 created "2016-06-24" @default.
• W2014993624 creator A5008790176 @default.
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• W2014993624 creator A5028085268 @default.
• W2014993624 creator A5091253086 @default.
• W2014993624 date "2013-06-01" @default.
• W2014993624 modified "2023-10-01" @default.
• W2014993624 title "Uncommon Epidermal Growth Factor Receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance" @default.
• W2014993624 cites W1514134885 @default.
• W2014993624 cites W1965129132 @default.
• W2014993624 cites W1967394241 @default.
• W2014993624 cites W1975276584 @default.
• W2014993624 cites W1979332174 @default.
• W2014993624 cites W1980497534 @default.
• W2014993624 cites W1982397643 @default.
• W2014993624 cites W1987709860 @default.
• W2014993624 cites W2002937040 @default.
• W2014993624 cites W2003984225 @default.
• W2014993624 cites W2005728761 @default.
• W2014993624 cites W2006315580 @default.
• W2014993624 cites W2006505028 @default.
• W2014993624 cites W2015217502 @default.
• W2014993624 cites W2018217352 @default.
• W2014993624 cites W2022670843 @default.
• W2014993624 cites W2023532383 @default.
• W2014993624 cites W2028003167 @default.
• W2014993624 cites W2028015151 @default.
• W2014993624 cites W2029441111 @default.
• W2014993624 cites W2030165415 @default.
• W2014993624 cites W2030662132 @default.
• W2014993624 cites W2033780390 @default.
• W2014993624 cites W2037873277 @default.
• W2014993624 cites W2043281927 @default.
• W2014993624 cites W2043696829 @default.
• W2014993624 cites W2045486039 @default.
• W2014993624 cites W2048538776 @default.
• W2014993624 cites W2048733384 @default.
• W2014993624 cites W2050866238 @default.
• W2014993624 cites W2056099081 @default.
• W2014993624 cites W2056480599 @default.
• W2014993624 cites W2063391304 @default.
• W2014993624 cites W2068864761 @default.
• W2014993624 cites W2071042296 @default.
• W2014993624 cites W2076865148 @default.
• W2014993624 cites W2081269875 @default.
• W2014993624 cites W2085791457 @default.
• W2014993624 cites W2090029719 @default.
• W2014993624 cites W2090066097 @default.
• W2014993624 cites W2093166014 @default.
• W2014993624 cites W2095618958 @default.
• W2014993624 cites W2096786080 @default.
• W2014993624 cites W2098674632 @default.
• W2014993624 cites W2100794900 @default.
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• W2014993624 cites W2102088611 @default.
• W2014993624 cites W2103388071 @default.
• W2014993624 cites W2106297623 @default.
• W2014993624 cites W2107304950 @default.
• W2014993624 cites W2108287705 @default.
• W2014993624 cites W2109080255 @default.
• W2014993624 cites W2110841878 @default.
• W2014993624 cites W2111109297 @default.
• W2014993624 cites W2111973486 @default.
• W2014993624 cites W2114032749 @default.
• W2014993624 cites W2120598067 @default.
• W2014993624 cites W2122080749 @default.
• W2014993624 cites W2128215249 @default.
• W2014993624 cites W2131351052 @default.
• W2014993624 cites W2132166432 @default.
• W2014993624 cites W2133051701 @default.
• W2014993624 cites W2133963438 @default.
• W2014993624 cites W2138312420 @default.
• W2014993624 cites W2143859186 @default.
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• W2014993624 doi "https://doi.org/10.1016/j.lungcan.2013.01.018" @default.
• W2014993624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23485129" @default.
• W2014993624 hasPublicationYear "2013" @default.
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