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- W2014993871 abstract "Objective: Evaluate hypertension prevalence in lupus cohort, study its epidemiologic profile, diagnostic, therapeutic and outcome. Design and Method: Among 156 lupus patients, 16 hypertensive were included. Clinical information were collected. Baseline characteristics: sex, hypertension personal and family history, treatment, traditional cardiac risk factors, clinical presentation and renal outcome were recorded. Results and Conclusions: Mean age at time of diagnosis was 34.4 ± 12.1 years. Mean lupus duration was 15.3 ± 7.2 years. Hypertension preceded lupus in 2 cases. Mean time between first symptom and hypertension was 34 months. Hypertension was initially present in 4, appeared after in 10, with a family history in 4 cases. More than 2 cardiac risk factors were present in 8 patients. Obesity was noted in 3 patients, diabetes mellitus in 2, dyslipidemia in 4, renal failure in 6, target organ disease and a high metabolic risk profile in 15 patients. Hypertension was concomitant to lupus nephritis in 7 and appeared after 52-month mean time in 4 cases. Kidney biopsy performed in 12 patients, yielded stage IV lupus nephritis in 8. Among 10 post-lupus onset hypertensive patients, 8 had received mean 45-month steroid therapy. Anti-cardiolipin anti-bodies, lupus anticoagulant were positives in 7 and 3 cases. Three presented antiphospholipid syndrome. Etiologic enquiry revealed lupus nephritis and/or antiphospholipid syndrome induced hypertension in 13 cases. Remaining cases were considered as essential or iatrogenic. Mono-, bi- and tritherapy were prescribed in 6, 6 and 2 cases, respectively. Follow-up was 55months. Blood pressure was less than 130/80, between 130/80 and 140/90mmHg and uncontrolled in 10, 2 and 3, respectively. Chronic renal failure was noted in 4 cases and 3 patients were hemodialyzed. Hypertension is a bad renal prognosis factor and cardiac risk factor. Controlling renal involvement and optimizing body weight may prevent the occurrence of hypertension. An early diagnosis, a tight surveillance and strict therapeutic control of blood pressure are mandatory in lupus patients to prevent and ovoid cardio-vascular complications and renal function worsening." @default.
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- W2014993871 date "2010-06-01" @default.
- W2014993871 modified "2023-10-16" @default.
- W2014993871 title "HYPERTENSION IN SYSTEMIC LUPUS ERYTHEMATOSUS: PP.15.60" @default.
- W2014993871 doi "https://doi.org/10.1097/01.hjh.0000378986.14139.c4" @default.
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