FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014994931> ?p ?o ?g. }

• W2014994931 endingPage "683" @default.
• W2014994931 startingPage "677" @default.
• W2014994931 abstract "Pancreatic cancer is an aggressive disease that responds poorly to conventional photon radiotherapy. Carbon-ion (C-ion) radiation has advantages compared with conventional radiotherapy, because it enables more accurate dose distribution and more efficient tumor cell killing. To elucidate the effects of local radiotherapy on the characteristics of metastatic tumors, it is necessary to understand the nature of motility in irradiated tumor cells; this will, in turn, facilitate the development of effective strategies to counter tumor cell motility, which can be used in combination with radiotherapy. The aim of the present study was to examine the invasiveness of pancreatic cancer cells exposed to C-ion irradiation. We found that C-ion irradiation suppressed the migration of MIAPaCa-2, BxPC-3 and AsPC-1; diminished the invasiveness of MIAPaCa-2; and tended to reduce the invasion of BxPC-3 and AsPC-1. However, C-ion irradiation increased the invasiveness of PANC-1 through the activation of plasmin and urokinase-type plasiminogen activator. Administration of serine protease inhibitor (SerPI) alone failed to reduce C-ion-induced PANC-1 invasiveness, whereas the combination of SerPI and Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor suppressed it. Furthermore, PANC-1 showed mesenchymal–amoeboid transition when we treated with SerPI alone. In conclusion, C-ion irradiation is effective in suppressing the invasive potential of several pancreatic tumor cell lines, but not PANC-1; this is the first study showing that C-ion irradiation induces the invasive potential of a tumor cell line. Further in vivo studies are required to examine the therapeutic effectiveness of radiotherapy combined with inhibitors of both mesenchymal and amoeboid modes of tumor cell motility. (Cancer Sci 2012; 103: 677–683)" @default.
• W2014994931 created "2016-06-24" @default.
• W2014994931 creator A5023842343 @default.
• W2014994931 creator A5029489298 @default.
• W2014994931 creator A5050051831 @default.
• W2014994931 creator A5059319405 @default.
• W2014994931 creator A5076684341 @default.
• W2014994931 creator A5091049484 @default.
• W2014994931 date "2012-01-20" @default.
• W2014994931 modified "2023-10-10" @default.
• W2014994931 title "Carbon-ion radiation enhances migration ability and invasiveness of the pancreatic cancer cell, PANC-1, in vitro" @default.
• W2014994931 cites W1968386889 @default.
• W2014994931 cites W1968783143 @default.
• W2014994931 cites W1984086927 @default.
• W2014994931 cites W1997104566 @default.
• W2014994931 cites W1999088044 @default.
• W2014994931 cites W2011816149 @default.
• W2014994931 cites W2015782123 @default.
• W2014994931 cites W2016613877 @default.
• W2014994931 cites W2022318100 @default.
• W2014994931 cites W2028040595 @default.
• W2014994931 cites W2029043965 @default.
• W2014994931 cites W2031513432 @default.
• W2014994931 cites W2039769899 @default.
• W2014994931 cites W2047349747 @default.
• W2014994931 cites W2051600139 @default.
• W2014994931 cites W2055800277 @default.
• W2014994931 cites W2059180671 @default.
• W2014994931 cites W2078694386 @default.
• W2014994931 cites W2088250735 @default.
• W2014994931 cites W2092565468 @default.
• W2014994931 cites W2095483969 @default.
• W2014994931 cites W2098443648 @default.
• W2014994931 cites W2100975996 @default.
• W2014994931 cites W2106505027 @default.
• W2014994931 cites W2107632463 @default.
• W2014994931 cites W2126117802 @default.
• W2014994931 cites W2127611014 @default.
• W2014994931 cites W2129926378 @default.
• W2014994931 cites W2133054656 @default.
• W2014994931 cites W2135351121 @default.
• W2014994931 cites W2146278300 @default.
• W2014994931 cites W2160994657 @default.
• W2014994931 cites W2164921896 @default.
• W2014994931 cites W2166676532 @default.
• W2014994931 doi "https://doi.org/10.1111/j.1349-7006.2011.02190.x" @default.
• W2014994931 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7713567" @default.
• W2014994931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22171596" @default.
• W2014994931 hasPublicationYear "2012" @default.
• W2014994931 type Work @default.
• W2014994931 sameAs 2014994931 @default.
• W2014994931 citedByCount "40" @default.
• W2014994931 countsByYear W20149949312012 @default.
• W2014994931 countsByYear W20149949312013 @default.
• W2014994931 countsByYear W20149949312014 @default.
• W2014994931 countsByYear W20149949312015 @default.
• W2014994931 countsByYear W20149949312016 @default.
• W2014994931 countsByYear W20149949312017 @default.
• W2014994931 countsByYear W20149949312018 @default.
• W2014994931 countsByYear W20149949312019 @default.
• W2014994931 countsByYear W20149949312020 @default.
• W2014994931 countsByYear W20149949312021 @default.
• W2014994931 countsByYear W20149949312022 @default.
• W2014994931 countsByYear W20149949312023 @default.
• W2014994931 crossrefType "journal-article" @default.
• W2014994931 hasAuthorship W2014994931A5023842343 @default.
• W2014994931 hasAuthorship W2014994931A5029489298 @default.
• W2014994931 hasAuthorship W2014994931A5050051831 @default.
• W2014994931 hasAuthorship W2014994931A5059319405 @default.
• W2014994931 hasAuthorship W2014994931A5076684341 @default.
• W2014994931 hasAuthorship W2014994931A5091049484 @default.
• W2014994931 hasBestOaLocation W20149949311 @default.
• W2014994931 hasConcept C121608353 @default.
• W2014994931 hasConcept C126322002 @default.
• W2014994931 hasConcept C137738243 @default.
• W2014994931 hasConcept C150903083 @default.
• W2014994931 hasConcept C181199279 @default.
• W2014994931 hasConcept C185592680 @default.
• W2014994931 hasConcept C202751555 @default.
• W2014994931 hasConcept C207001950 @default.
• W2014994931 hasConcept C2777996000 @default.
• W2014994931 hasConcept C2779013556 @default.
• W2014994931 hasConcept C2780210213 @default.
• W2014994931 hasConcept C2781071845 @default.
• W2014994931 hasConcept C502942594 @default.
• W2014994931 hasConcept C509974204 @default.
• W2014994931 hasConcept C55493867 @default.
• W2014994931 hasConcept C58207958 @default.
• W2014994931 hasConcept C71924100 @default.
• W2014994931 hasConcept C86803240 @default.
• W2014994931 hasConcept C95444343 @default.
• W2014994931 hasConceptScore W2014994931C121608353 @default.
• W2014994931 hasConceptScore W2014994931C126322002 @default.
• W2014994931 hasConceptScore W2014994931C137738243 @default.
• W2014994931 hasConceptScore W2014994931C150903083 @default.
• W2014994931 hasConceptScore W2014994931C181199279 @default.
• W2014994931 hasConceptScore W2014994931C185592680 @default.
• W2014994931 hasConceptScore W2014994931C202751555 @default.

• next