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- W2014995859 abstract "Abstract Male C57BL/6 mice were administered either morphine, phenobarbital or ethanol in their drinking water in order to make them dependent. During withdrawal onset of myoclonus, clonus and tonus was evaluated with flurothyl, a convulsant inhalant. Morphine, phenobarbital and ethanol treated subjects displayed significantly lower latencies for myoclonic and clonic convulsive behavior when compared with their respective controls. The increased CNS excitability observed is characteristic of physical dependence and the flurothyl technique employed is discussed in light of its broad applicability to a number of agents characterized by their dependence producing properties." @default.
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- W2014995859 date "1976-06-01" @default.
- W2014995859 modified "2023-09-27" @default.
- W2014995859 title "Increased CNS sensitivity to flurothyl as a measure of physical dependence in mice following morphine, phenobarbital, and ethanol treatment" @default.
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- W2014995859 doi "https://doi.org/10.1016/0024-3205(76)90353-2" @default.
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