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- W2014996366 abstract "Recent studies indicate that C-peptide, when given to patients with insulin-dependent (Type 1) diabetes mellitus (IDDM), exerts significant effects on microvascular and neuronal functions. Adjuvant therapy with C-peptide has been advocated in the treatment of IDDM patients. Since endogenous insulin secretion is believed to be of importance for the alpha-cell function, we addressed the issue whether C-peptide given acutely interferes with the responses to hypoglycaemia. Seven IDDM patients were randomly exposed to hypoglycaemia with and without exogenous C-peptide. Insulin and and C-peptide were given intravenously in equimolar amounts for 3 hours. The decrease of blood glucose was faster and more pronounced during C-peptide infusion, yielding a significantly lower AUC 0–180 min of blood glucose (38.5 ± 1.6 vs 44.4 ± 2.2 mmol l−1 h−1 ; p = 0.032). No difference between the two experiments was found concerning glucagon when the AUC, Δ-values or levels at separate points of time were calculated. In conclusion, the main finding of this study was that exogenous C-peptide, given acutely, gave rise to a more rapid onset of hypoglycaemia yielding no detectable differences with respect to the response of glucagon and other counterregulatory hormones. © 1997 by John Wiley & Sons, Ltd." @default.
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- W2014996366 date "1997-08-01" @default.
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- W2014996366 title "Effects of C-peptide on insulin-induced hypoglycaemia and its counterregulatory responses in IDDM patients" @default.
- W2014996366 doi "https://doi.org/10.1002/(sici)1096-9136(199708)14:8<655::aid-dia435>3.0.co;2-g" @default.
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