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- W2014996904 abstract "The β-adrenoceptor (β-AR) subtypes mediating relaxation of the rabbit, rat and canine detrusors were subjected to functional investigation using selective β-AR agonists and antagonists. In all three species, isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the detrusor. The rank order for their relaxing potency was isoprenaline> adrenaline>noradrenaline in rabbits and rats, but isoprenaline>noradrenaline>adrenaline in dogs. Dobutamine did not produce relaxation of the detrusors at concentrations that are selective for β1-AR. The selective β2-AR agonist, procaterol, had a more potent relaxing effect on rabbit and rat detrusors than on the canine detrusor. CGP-12177A, a selective β3-AR agonist, was more effective in the rabbit than in the other two species. On the other hand, the relaxing effect of another β3-AR agonist, CL316243, was more pronounced in dogs and rats than in rabbits. CGP-20712A (10−9 to 10−7 M), a selective β1-AR antagonist, caused a slight rightward shift of the concentration-relaxation response curve for isoprenaline in the canine detrusor (pA2 9.41), but not in the rabbit and rat detrusors. ICI-118,551, a selective β2-AR antagonist, antagonized the isoprenaline-induced relaxation in rabbits (pA2 9.45) and rats (pA2 9.05), but not in dogs. Bupranolol, a non-selective β-AR antagonist, caused a rightward shift of the concentration-relaxation curve for isoprenaline in the rabbit (pA2 9.32) and rat (pA2 8.98). However, higher concentrations (3×10−8 to 10−5 M) were needed to induce a rightward shift of the curve for isoprenaline in the dog (pA2 8.19) than in the other two species. We have confirmed that the distribution of β-AR subtypes in the detrusor muscle varies significantly from species to species and we provide here the first evidence of the presence of β3-AR in the detrusor. It is suggested that the relaxation induced by adrenoceptor agonists in urinary bladder smooth muscle may be mediated mainly via β2-AR in rabbits, via both β2- and β3-AR in rats, but mainly via β3-AR in dogs." @default.
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- W2014996904 date "1998-06-01" @default.
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- W2014996904 title "Species differences in the distribution of <i>β</i> -adrenoceptor subtypes in bladder smooth muscle" @default.
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- W2014996904 doi "https://doi.org/10.1038/sj.bjp.0701870" @default.
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