Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014997555> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2014997555 endingPage "58" @default.
- W2014997555 startingPage "54" @default.
- W2014997555 abstract "Retrovirus genomic mRNA exhibits a several hundred nucleotides-long untranslated region (5′ UTR) which encloses many control elements required for retrovirus replication. In addition, this 5′ UTR contains translation regulatory elements, such as internal ribosome entry sites (IRESes) that have been described in oncoretroviruses, as well as in lentiviruses. UV cross-linking experiments suggested that the pyrimidine tract binding protein (PTB), a cellular protein known to regulate the activity of several picornaviral IRESes, binds to human T-cell leukemia virus (HTLV)-I RNA but not to lentiviral human immunodeficiency virus (HIV)-1, HIV-2 or simian immunodeficiency virus RNAs. To calculate the affinity of such RNA–protein interactions, we developed a new method based on the BIAcore technology. The absence of affinity of PTB for lentiviral RNAs was confirmed, whereas its affinity for HTLV-I RNAs was 1000-fold lower than for picornaviral RNAs. The BIAcore technology also revealed a significant affinity of the La autoantigen, previously described for its involvement in translational control of viral mRNAs, for HIV-1 and HTLV-I RNAs. Addition of recombinant PTB to in vitro translation experiments weakly enhanced translation initiation in the presence of HTLV-I IRES, suggesting that such an IRES requires additional trans-acting factors." @default.
- W2014997555 created "2016-06-24" @default.
- W2014997555 creator A5027756814 @default.
- W2014997555 creator A5034994959 @default.
- W2014997555 creator A5064639315 @default.
- W2014997555 creator A5067577762 @default.
- W2014997555 creator A5072633078 @default.
- W2014997555 date "2001-02-09" @default.
- W2014997555 modified "2023-10-10" @default.
- W2014997555 title "Pyrimidine tract binding protein and La autoantigen interact differently with the 5′ untranslated regions of lentiviruses and oncoretrovirus mRNAs" @default.
- W2014997555 cites W1620364639 @default.
- W2014997555 cites W1747266960 @default.
- W2014997555 cites W1822195738 @default.
- W2014997555 cites W2000837190 @default.
- W2014997555 cites W2008703312 @default.
- W2014997555 cites W2009598373 @default.
- W2014997555 cites W2030800602 @default.
- W2014997555 cites W2070571930 @default.
- W2014997555 cites W2099571103 @default.
- W2014997555 cites W2103410475 @default.
- W2014997555 cites W2112503642 @default.
- W2014997555 cites W2271083769 @default.
- W2014997555 cites W4250467272 @default.
- W2014997555 doi "https://doi.org/10.1016/s0014-5793(01)02137-8" @default.
- W2014997555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11172810" @default.
- W2014997555 hasPublicationYear "2001" @default.
- W2014997555 type Work @default.
- W2014997555 sameAs 2014997555 @default.
- W2014997555 citedByCount "21" @default.
- W2014997555 countsByYear W20149975552013 @default.
- W2014997555 countsByYear W20149975552016 @default.
- W2014997555 countsByYear W20149975552018 @default.
- W2014997555 countsByYear W20149975552020 @default.
- W2014997555 countsByYear W20149975552022 @default.
- W2014997555 crossrefType "journal-article" @default.
- W2014997555 hasAuthorship W2014997555A5027756814 @default.
- W2014997555 hasAuthorship W2014997555A5034994959 @default.
- W2014997555 hasAuthorship W2014997555A5064639315 @default.
- W2014997555 hasAuthorship W2014997555A5067577762 @default.
- W2014997555 hasAuthorship W2014997555A5072633078 @default.
- W2014997555 hasBestOaLocation W20149975551 @default.
- W2014997555 hasConcept C104317684 @default.
- W2014997555 hasConcept C105580179 @default.
- W2014997555 hasConcept C114847915 @default.
- W2014997555 hasConcept C149364088 @default.
- W2014997555 hasConcept C153911025 @default.
- W2014997555 hasConcept C159047783 @default.
- W2014997555 hasConcept C161295673 @default.
- W2014997555 hasConcept C2522874641 @default.
- W2014997555 hasConcept C2778431562 @default.
- W2014997555 hasConcept C39685955 @default.
- W2014997555 hasConcept C55493867 @default.
- W2014997555 hasConcept C67705224 @default.
- W2014997555 hasConcept C77430603 @default.
- W2014997555 hasConcept C86803240 @default.
- W2014997555 hasConcept C88478588 @default.
- W2014997555 hasConcept C89604277 @default.
- W2014997555 hasConceptScore W2014997555C104317684 @default.
- W2014997555 hasConceptScore W2014997555C105580179 @default.
- W2014997555 hasConceptScore W2014997555C114847915 @default.
- W2014997555 hasConceptScore W2014997555C149364088 @default.
- W2014997555 hasConceptScore W2014997555C153911025 @default.
- W2014997555 hasConceptScore W2014997555C159047783 @default.
- W2014997555 hasConceptScore W2014997555C161295673 @default.
- W2014997555 hasConceptScore W2014997555C2522874641 @default.
- W2014997555 hasConceptScore W2014997555C2778431562 @default.
- W2014997555 hasConceptScore W2014997555C39685955 @default.
- W2014997555 hasConceptScore W2014997555C55493867 @default.
- W2014997555 hasConceptScore W2014997555C67705224 @default.
- W2014997555 hasConceptScore W2014997555C77430603 @default.
- W2014997555 hasConceptScore W2014997555C86803240 @default.
- W2014997555 hasConceptScore W2014997555C88478588 @default.
- W2014997555 hasConceptScore W2014997555C89604277 @default.
- W2014997555 hasIssue "1-2" @default.
- W2014997555 hasLocation W20149975551 @default.
- W2014997555 hasLocation W20149975552 @default.
- W2014997555 hasOpenAccess W2014997555 @default.
- W2014997555 hasPrimaryLocation W20149975551 @default.
- W2014997555 hasRelatedWork W1493069978 @default.
- W2014997555 hasRelatedWork W2017584623 @default.
- W2014997555 hasRelatedWork W2060164191 @default.
- W2014997555 hasRelatedWork W2063058717 @default.
- W2014997555 hasRelatedWork W2072284483 @default.
- W2014997555 hasRelatedWork W2077921152 @default.
- W2014997555 hasRelatedWork W2232117585 @default.
- W2014997555 hasRelatedWork W2350309827 @default.
- W2014997555 hasRelatedWork W2419044071 @default.
- W2014997555 hasRelatedWork W3154155807 @default.
- W2014997555 hasVolume "490" @default.
- W2014997555 isParatext "false" @default.
- W2014997555 isRetracted "false" @default.
- W2014997555 magId "2014997555" @default.
- W2014997555 workType "article" @default.