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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014999901> ?p ?o ?g. }

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• W2014999901 abstract "The purpose of this study was to determine whether the local sustained production of murine interferon beta (mIFN-beta) could inhibit the growth of human ovarian cancer cells in the peritoneal cavity of nude mice. Human ovarian tumor Hey-A8 cells transfected with mIFN-beta (Hey-beta) or a control neomycin resistance vector (Hey-Neo) grew well in culture. Tumor cells were injected into the peritoneal cavity or under the subcutis of nuce mice. Parental (wild-type) or control transfected cells produced large tumors, whereas mIFN-beta-transfected cells did not produce any tumors. The IFN-beta-transfected cells prevented the outgrowth of bystander parental, control-transfected cells, and another human ovarian tumor cell line, SKOV3i.p.1, in the peritoneal cavity of nude mice. The IFN-beta-transfected tumor cells stimulated a high level of nitric oxide (NO) production in murine macrophages under both in vitro and in vivo conditions, and only the NO-producing macrophages exhibited antitumor activity. Collectively, these results demonstrate that the local production of IFN-beta can inhibit the in vivo growth of human ovarian cancer cells by upregulating the expression of the inducible nitric oxide synthase (iNOS) gene in host macrophages." @default.
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• W2014999901 date "1998-12-10" @default.
• W2014999901 modified "2023-10-09" @default.
• W2014999901 title "Therapy of Human Ovarian Cancer by Transfection with the Murine Interferon<i>β</i>Gene: Role of Macrophage-Inducible Nitric Oxide Synthase" @default.
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• W2014999901 doi "https://doi.org/10.1089/hum.1998.9.18-2699" @default.
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