Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015010151> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2015010151 endingPage "579" @default.
- W2015010151 startingPage "568" @default.
- W2015010151 abstract "During preimplantation development in the mouse, two phenotypically distinct cell populations appear at the 16-cell stage: nonpolarized inner cells that give rise to the inner cell mass and polarized outer cells that give rise mainly to the trophectoderm. The divergence of these two cell lineages is due to asymmetrical cell divisions during the transition from the 8- to the 16 cell stage which can occur following blastomere polarization. During compaction, at the 8-cell stage, cytoplasmic organelles accumulate in the apical domain, a surface pole of microvilli forms, and blastomeres flatten onto one another. During the division from the 8- to the 16-cell stage, the only asymmetrical structure maintained is the pole of microvilli. At the 16-cell stage, only blastomeres inheriting a large part of this apical structure can reestablish a polarized organization. The mechanisms involved in the formation and stabilization of the apical pole of microvilli are still unknown. Ezrin is an actin-associated protein that has been proposed to play a role in the formation of microvillous structures. This led us to study the expression of ezrin during early development of the mouse embryo. We observed that ezrin mRNA and protein are present in the mouse oocyte and throughout preimplantation embryo development, although the amount of protein present decreases continuously during early development, particularly after the 8-cell stage, at the time of compaction. Two isoforms of ezrin phosphorylated on tyrosine residues are present during all of preimplantation development while a third non-tyrosine-phosphorylated isoform appears at the 8-cell stage and its relative amount increases from the 8-cell stage to the blastocyst stage. Before compaction, ezrin is distributed around the cell cortex. However ezrin becomes restricted to the microvilli of the apical pole after compaction. At later stages, ezrin is found in the microvilli of the apical surface of outer cells. Finally, ezrin remains associated with the microvillous pole during the transition from the 8- to 16-cell stage and is found only in the outer cells after division. Thus, ezrin is the first cytocortical protein described that is totally segregated in outer cells at the 16-cell stage after an asymmetrical division." @default.
- W2015010151 created "2016-06-24" @default.
- W2015010151 creator A5000821904 @default.
- W2015010151 creator A5027793634 @default.
- W2015010151 creator A5036857513 @default.
- W2015010151 creator A5079816714 @default.
- W2015010151 creator A5089965319 @default.
- W2015010151 date "1996-08-01" @default.
- W2015010151 modified "2023-10-16" @default.
- W2015010151 title "Ezrin Becomes Restricted to Outer Cells Following Asymmetrical Division in the Preimplantation Mouse Embryo" @default.
- W2015010151 doi "https://doi.org/10.1006/dbio.1996.0186" @default.
- W2015010151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8806832" @default.
- W2015010151 hasPublicationYear "1996" @default.
- W2015010151 type Work @default.
- W2015010151 sameAs 2015010151 @default.
- W2015010151 citedByCount "134" @default.
- W2015010151 countsByYear W20150101512012 @default.
- W2015010151 countsByYear W20150101512013 @default.
- W2015010151 countsByYear W20150101512014 @default.
- W2015010151 countsByYear W20150101512015 @default.
- W2015010151 countsByYear W20150101512016 @default.
- W2015010151 countsByYear W20150101512017 @default.
- W2015010151 countsByYear W20150101512018 @default.
- W2015010151 countsByYear W20150101512019 @default.
- W2015010151 countsByYear W20150101512020 @default.
- W2015010151 countsByYear W20150101512021 @default.
- W2015010151 countsByYear W20150101512022 @default.
- W2015010151 countsByYear W20150101512023 @default.
- W2015010151 crossrefType "journal-article" @default.
- W2015010151 hasAuthorship W2015010151A5000821904 @default.
- W2015010151 hasAuthorship W2015010151A5027793634 @default.
- W2015010151 hasAuthorship W2015010151A5036857513 @default.
- W2015010151 hasAuthorship W2015010151A5079816714 @default.
- W2015010151 hasAuthorship W2015010151A5089965319 @default.
- W2015010151 hasBestOaLocation W20150101511 @default.
- W2015010151 hasConcept C129536746 @default.
- W2015010151 hasConcept C142669718 @default.
- W2015010151 hasConcept C1491633281 @default.
- W2015010151 hasConcept C159399396 @default.
- W2015010151 hasConcept C190062978 @default.
- W2015010151 hasConcept C196843134 @default.
- W2015010151 hasConcept C2776292417 @default.
- W2015010151 hasConcept C2778177303 @default.
- W2015010151 hasConcept C2780246058 @default.
- W2015010151 hasConcept C45472230 @default.
- W2015010151 hasConcept C49353375 @default.
- W2015010151 hasConcept C54355233 @default.
- W2015010151 hasConcept C68760520 @default.
- W2015010151 hasConcept C85813293 @default.
- W2015010151 hasConcept C86803240 @default.
- W2015010151 hasConcept C87073359 @default.
- W2015010151 hasConcept C95444343 @default.
- W2015010151 hasConceptScore W2015010151C129536746 @default.
- W2015010151 hasConceptScore W2015010151C142669718 @default.
- W2015010151 hasConceptScore W2015010151C1491633281 @default.
- W2015010151 hasConceptScore W2015010151C159399396 @default.
- W2015010151 hasConceptScore W2015010151C190062978 @default.
- W2015010151 hasConceptScore W2015010151C196843134 @default.
- W2015010151 hasConceptScore W2015010151C2776292417 @default.
- W2015010151 hasConceptScore W2015010151C2778177303 @default.
- W2015010151 hasConceptScore W2015010151C2780246058 @default.
- W2015010151 hasConceptScore W2015010151C45472230 @default.
- W2015010151 hasConceptScore W2015010151C49353375 @default.
- W2015010151 hasConceptScore W2015010151C54355233 @default.
- W2015010151 hasConceptScore W2015010151C68760520 @default.
- W2015010151 hasConceptScore W2015010151C85813293 @default.
- W2015010151 hasConceptScore W2015010151C86803240 @default.
- W2015010151 hasConceptScore W2015010151C87073359 @default.
- W2015010151 hasConceptScore W2015010151C95444343 @default.
- W2015010151 hasIssue "2" @default.
- W2015010151 hasLocation W20150101511 @default.
- W2015010151 hasLocation W20150101512 @default.
- W2015010151 hasOpenAccess W2015010151 @default.
- W2015010151 hasPrimaryLocation W20150101511 @default.
- W2015010151 hasRelatedWork W1539528634 @default.
- W2015010151 hasRelatedWork W2024028178 @default.
- W2015010151 hasRelatedWork W2032682166 @default.
- W2015010151 hasRelatedWork W2061452470 @default.
- W2015010151 hasRelatedWork W2080377199 @default.
- W2015010151 hasRelatedWork W2161535630 @default.
- W2015010151 hasRelatedWork W2180688031 @default.
- W2015010151 hasRelatedWork W2381768210 @default.
- W2015010151 hasRelatedWork W2559944693 @default.
- W2015010151 hasRelatedWork W3041678034 @default.
- W2015010151 hasVolume "177" @default.
- W2015010151 isParatext "false" @default.
- W2015010151 isRetracted "false" @default.
- W2015010151 magId "2015010151" @default.
- W2015010151 workType "article" @default.