FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015010345> ?p ?o ?g. }

• W2015010345 endingPage "966" @default.
• W2015010345 startingPage "961" @default.
• W2015010345 abstract "In humans, autologous transplants derived from bone marrow (BM) usually engraft more slowly than transplants derived from mobilized peripheral blood. Allogeneic BM transplants show a further delay in engraftment and have an apparent requirement for donor T cells to facilitate engraftment. In mice, Thy-1.1(lo)Lin-/loSca-1+ hematopoietic stem cells (HSCs) are the principal population in BM which is responsible for engraftment in syngeneic hosts at radioprotective doses, and higher doses of HSCs can radioprotect an allogeneic host in the absence of donor T cells. Using the mouse as a preclinical model, we wished to test to what extent engraftment kinetics was a function of HSC content, and whether at high doses of c-Kit+Thy-1.1(lo)Lin-/loSca-1+ (KTLS) cells rapid allogeneic engraftment could also be achieved. Here we demonstrate that engraftment kinetics varied greatly over the range of KTLS doses tested (100-10,000 cells), with the most rapid engraftment being obtained with a dose of 5,000 or more syngeneic cells. Mobilized splenic KTLS cells and the rhodamine 123(lo) subset of KTLS cells were also able to engraft rapidly. Higher doses of allogeneic cells were needed to produce equivalent engraftment kinetics. This suggests that in mice even fully allogeneic barriers can be traversed with high doses of HSCs, and that in humans it may be possible to obtain rapid engraftment in an allogeneic context with clinically achievable doses of purified HSCs." @default.
• W2015010345 created "2016-06-24" @default.
• W2015010345 creator A5029150372 @default.
• W2015010345 creator A5043439522 @default.
• W2015010345 creator A5048743123 @default.
• W2015010345 creator A5076768806 @default.
• W2015010345 creator A5082894731 @default.
• W2015010345 creator A5085316776 @default.
• W2015010345 date "1998-03-01" @default.
• W2015010345 modified "2023-10-18" @default.
• W2015010345 title "High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts." @default.
• W2015010345 cites W124001930 @default.
• W2015010345 cites W1479673257 @default.
• W2015010345 cites W153436937 @default.
• W2015010345 cites W1606620269 @default.
• W2015010345 cites W1637329404 @default.
• W2015010345 cites W1973035870 @default.
• W2015010345 cites W1995286997 @default.
• W2015010345 cites W2070479513 @default.
• W2015010345 cites W2087919417 @default.
• W2015010345 cites W2098672716 @default.
• W2015010345 cites W2138993111 @default.
• W2015010345 cites W2150526928 @default.
• W2015010345 cites W2154992787 @default.
• W2015010345 cites W2168757635 @default.
• W2015010345 cites W2215329342 @default.
• W2015010345 cites W2285961883 @default.
• W2015010345 cites W2287821239 @default.
• W2015010345 cites W2411716823 @default.
• W2015010345 cites W2415222803 @default.
• W2015010345 cites W98258303 @default.
• W2015010345 doi "https://doi.org/10.1172/jci1681" @default.
• W2015010345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508646" @default.
• W2015010345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9486965" @default.
• W2015010345 hasPublicationYear "1998" @default.
• W2015010345 type Work @default.
• W2015010345 sameAs 2015010345 @default.
• W2015010345 citedByCount "137" @default.
• W2015010345 countsByYear W20150103452012 @default.
• W2015010345 countsByYear W20150103452013 @default.
• W2015010345 countsByYear W20150103452015 @default.
• W2015010345 countsByYear W20150103452016 @default.
• W2015010345 countsByYear W20150103452017 @default.
• W2015010345 countsByYear W20150103452018 @default.
• W2015010345 countsByYear W20150103452019 @default.
• W2015010345 countsByYear W20150103452020 @default.
• W2015010345 countsByYear W20150103452021 @default.
• W2015010345 countsByYear W20150103452022 @default.
• W2015010345 countsByYear W20150103452023 @default.
• W2015010345 crossrefType "journal-article" @default.
• W2015010345 hasAuthorship W2015010345A5029150372 @default.
• W2015010345 hasAuthorship W2015010345A5043439522 @default.
• W2015010345 hasAuthorship W2015010345A5048743123 @default.
• W2015010345 hasAuthorship W2015010345A5076768806 @default.
• W2015010345 hasAuthorship W2015010345A5082894731 @default.
• W2015010345 hasAuthorship W2015010345A5085316776 @default.
• W2015010345 hasBestOaLocation W20150103451 @default.
• W2015010345 hasConcept C109159458 @default.
• W2015010345 hasConcept C126322002 @default.
• W2015010345 hasConcept C151730666 @default.
• W2015010345 hasConcept C203014093 @default.
• W2015010345 hasConcept C2779343474 @default.
• W2015010345 hasConcept C2780007613 @default.
• W2015010345 hasConcept C28328180 @default.
• W2015010345 hasConcept C2908647359 @default.
• W2015010345 hasConcept C2911091166 @default.
• W2015010345 hasConcept C502942594 @default.
• W2015010345 hasConcept C71924100 @default.
• W2015010345 hasConcept C86803240 @default.
• W2015010345 hasConcept C95444343 @default.
• W2015010345 hasConcept C99454951 @default.
• W2015010345 hasConceptScore W2015010345C109159458 @default.
• W2015010345 hasConceptScore W2015010345C126322002 @default.
• W2015010345 hasConceptScore W2015010345C151730666 @default.
• W2015010345 hasConceptScore W2015010345C203014093 @default.
• W2015010345 hasConceptScore W2015010345C2779343474 @default.
• W2015010345 hasConceptScore W2015010345C2780007613 @default.
• W2015010345 hasConceptScore W2015010345C28328180 @default.
• W2015010345 hasConceptScore W2015010345C2908647359 @default.
• W2015010345 hasConceptScore W2015010345C2911091166 @default.
• W2015010345 hasConceptScore W2015010345C502942594 @default.
• W2015010345 hasConceptScore W2015010345C71924100 @default.
• W2015010345 hasConceptScore W2015010345C86803240 @default.
• W2015010345 hasConceptScore W2015010345C95444343 @default.
• W2015010345 hasConceptScore W2015010345C99454951 @default.
• W2015010345 hasIssue "5" @default.
• W2015010345 hasLocation W20150103451 @default.
• W2015010345 hasLocation W20150103452 @default.
• W2015010345 hasLocation W20150103453 @default.
• W2015010345 hasLocation W20150103454 @default.
• W2015010345 hasOpenAccess W2015010345 @default.
• W2015010345 hasPrimaryLocation W20150103451 @default.
• W2015010345 hasRelatedWork W1978598034 @default.
• W2015010345 hasRelatedWork W2038751426 @default.
• W2015010345 hasRelatedWork W2090080844 @default.
• W2015010345 hasRelatedWork W2162587612 @default.
• W2015010345 hasRelatedWork W2193032347 @default.
• W2015010345 hasRelatedWork W2253242983 @default.

• next