Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015011376> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2015011376 abstract "Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy. In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis. Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4). We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH). Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats. Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise). We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway." @default.
- W2015011376 created "2016-06-24" @default.
- W2015011376 creator A5017261720 @default.
- W2015011376 creator A5041426522 @default.
- W2015011376 creator A5057429726 @default.
- W2015011376 creator A5058569055 @default.
- W2015011376 creator A5070009351 @default.
- W2015011376 creator A5072776976 @default.
- W2015011376 creator A5084809477 @default.
- W2015011376 creator A5090825625 @default.
- W2015011376 date "1996-09-01" @default.
- W2015011376 modified "2023-09-23" @default.
- W2015011376 title "Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum." @default.
- W2015011376 cites W1497553313 @default.
- W2015011376 cites W1568529372 @default.
- W2015011376 cites W1574544450 @default.
- W2015011376 cites W1913640332 @default.
- W2015011376 cites W1990257386 @default.
- W2015011376 cites W1993243592 @default.
- W2015011376 cites W1998195903 @default.
- W2015011376 cites W2006773867 @default.
- W2015011376 cites W2021468772 @default.
- W2015011376 cites W2024193846 @default.
- W2015011376 cites W2049663671 @default.
- W2015011376 cites W2057737390 @default.
- W2015011376 cites W2058198227 @default.
- W2015011376 cites W2060633742 @default.
- W2015011376 cites W2081135713 @default.
- W2015011376 cites W2088094960 @default.
- W2015011376 cites W2091361275 @default.
- W2015011376 cites W2103320855 @default.
- W2015011376 cites W2107756893 @default.
- W2015011376 cites W2127874341 @default.
- W2015011376 cites W2132347745 @default.
- W2015011376 cites W2140706392 @default.
- W2015011376 cites W2159567970 @default.
- W2015011376 cites W2164983527 @default.
- W2015011376 cites W2333398204 @default.
- W2015011376 cites W2342171261 @default.
- W2015011376 cites W2467490546 @default.
- W2015011376 cites W2518926822 @default.
- W2015011376 doi "https://doi.org/10.1164/ajrccm.154.3.8810619" @default.
- W2015011376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8810619" @default.
- W2015011376 hasPublicationYear "1996" @default.
- W2015011376 type Work @default.
- W2015011376 sameAs 2015011376 @default.
- W2015011376 citedByCount "23" @default.
- W2015011376 countsByYear W20150113762013 @default.
- W2015011376 countsByYear W20150113762015 @default.
- W2015011376 countsByYear W20150113762016 @default.
- W2015011376 countsByYear W20150113762018 @default.
- W2015011376 countsByYear W20150113762019 @default.
- W2015011376 countsByYear W20150113762021 @default.
- W2015011376 crossrefType "journal-article" @default.
- W2015011376 hasAuthorship W2015011376A5017261720 @default.
- W2015011376 hasAuthorship W2015011376A5041426522 @default.
- W2015011376 hasAuthorship W2015011376A5057429726 @default.
- W2015011376 hasAuthorship W2015011376A5058569055 @default.
- W2015011376 hasAuthorship W2015011376A5070009351 @default.
- W2015011376 hasAuthorship W2015011376A5072776976 @default.
- W2015011376 hasAuthorship W2015011376A5084809477 @default.
- W2015011376 hasAuthorship W2015011376A5090825625 @default.
- W2015011376 hasConcept C126322002 @default.
- W2015011376 hasConcept C17991360 @default.
- W2015011376 hasConcept C203014093 @default.
- W2015011376 hasConcept C2776938444 @default.
- W2015011376 hasConcept C2778690821 @default.
- W2015011376 hasConcept C71924100 @default.
- W2015011376 hasConcept C98274493 @default.
- W2015011376 hasConceptScore W2015011376C126322002 @default.
- W2015011376 hasConceptScore W2015011376C17991360 @default.
- W2015011376 hasConceptScore W2015011376C203014093 @default.
- W2015011376 hasConceptScore W2015011376C2776938444 @default.
- W2015011376 hasConceptScore W2015011376C2778690821 @default.
- W2015011376 hasConceptScore W2015011376C71924100 @default.
- W2015011376 hasConceptScore W2015011376C98274493 @default.
- W2015011376 hasLocation W20150113761 @default.
- W2015011376 hasLocation W20150113762 @default.
- W2015011376 hasOpenAccess W2015011376 @default.
- W2015011376 hasPrimaryLocation W20150113761 @default.
- W2015011376 hasRelatedWork W1994050787 @default.
- W2015011376 hasRelatedWork W2002133510 @default.
- W2015011376 hasRelatedWork W2007151534 @default.
- W2015011376 hasRelatedWork W2012783542 @default.
- W2015011376 hasRelatedWork W2087976276 @default.
- W2015011376 hasRelatedWork W2146091000 @default.
- W2015011376 hasRelatedWork W2146127186 @default.
- W2015011376 hasRelatedWork W2334960750 @default.
- W2015011376 hasRelatedWork W2398878426 @default.
- W2015011376 hasRelatedWork W2412908045 @default.
- W2015011376 isParatext "false" @default.
- W2015011376 isRetracted "false" @default.
- W2015011376 magId "2015011376" @default.
- W2015011376 workType "article" @default.