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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015011507> ?p ?o ?g. }

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• W2015011507 abstract "PTEN-induced kinase 1 (PINK1) is a recently identified gene, mutations of which cause levodopa-responsive parkinsonism. An over-expression of wild-type PINK1 protects neurons from stress-induced mitochondrial dysfunction and apoptosis. We studied the effects of PINK1 suppression using small interfering RNA (siRNA), which can inhibit PINK1 mRNA expression up to 87%, and decrease PINK1 protein up to 80% in human dopaminergic cell line SH-SY5Y. Incubation with PINK1 siRNA decreased SH-SY5Y cell viability and significantly increased MPP(+) or rotenone-induced cytotoxicity. Our results indicate that reduction in PINK1 expression can trigger apoptotic process that can be exacerbated by the presence of MPP(+) or rotenone. These findings support the hypothesis that PINK1 participates in the protection of dopaminergic neurons." @default.
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• W2015011507 date "2005-12-01" @default.
• W2015011507 modified "2023-10-14" @default.
• W2015011507 title "Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y" @default.
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• W2015011507 doi "https://doi.org/10.1016/j.bbrc.2005.09.178" @default.
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