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• W2015013058 abstract "Birds, like mammals, have a highly polymorphic MHC that determines strong allograft rejection. However, in contrast to mammals, there are a number of viral diseases for which resistance and susceptibility are determined by particular chicken MHC haplotypes. We have found that certain common chicken MHC haplotypes express only one class I molecule at high levels. The selection on a single MHC gene should be strong, in contrast to the situation in mammals. We have determined the peptide motifs for the dominant class I molecules from a number of chicken MHC haplotypes and found that they can explain the outcome of infections with a small virus. However, the strongest MHC association is the resistance of the chicken B21 haplotype to classical Marek's disease virus, a relatively large pathogen for which any MHC molecule should find peptides. In 40 chicken lines, the level of class I expression correlates with the level of MHC-determined susceptibility to Marek's disease, the most susceptible B19 with the highest expression and the most resistant B21 with the lowest expression. Thus, cell surface expression level of class I molecules appears to be a polymorphism under selection by infectious pathogens, just like peptide-binding specificity. We speculate that these expression level differences are another manifestation of the simple MHC of chickens, which in human and mouse haplotypes are averaged out." @default.
• W2015013058 created "2016-06-24" @default.
• W2015013058 creator A5004814650 @default.
• W2015013058 creator A5041969299 @default.
• W2015013058 date "2004-05-11" @default.
• W2015013058 modified "2023-10-16" @default.
• W2015013058 title "The “Minimal Essential MHC” Revisited: Both Peptide-Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens" @default.
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• W2015013058 doi "https://doi.org/10.1111/j.1601-5223.1997.t01-1-00067.x" @default.
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