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- W2015013602 abstract "Oridonin (1), lasiokaurin (2), enmein (8), and enmein-3-acetate (9) and related compounds (3 and 10, ) all of which have α-methylene cyclopentanone function in their molecule, have been shown to have antitumor activity against Ehrlich ascites carcinoma inoculated into mice. These compounds have also indicated specific activity against gram-positive bacteria. On the other hand, oridonin dihydro-derivative (4), compound (5), trichokaurin (6), and dihydroenmein (11) show any activity against neither tumor nor bacteria. Thus, it is concluded that the α-methylene-cyclopentanone system must be an important active center. Biomimetic reactions of oridonin and enmein with several thiols etc. support this conclusion." @default.
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- W2015013602 date "1976-01-01" @default.
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- W2015013602 title "The antitumor and antibacterial activity of the Isodon diterpenoids." @default.
- W2015013602 doi "https://doi.org/10.1248/cpb.24.2118" @default.
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