Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015014748> ?p ?o ?g. }
- W2015014748 endingPage "1072" @default.
- W2015014748 startingPage "1063" @default.
- W2015014748 abstract "The acquisition of resistance to chemotherapy is a significant problem in the treatment of cancer, greatly increasing patient morbidity and mortality. Tumors are often sensitive to chemotherapy upon initial treatment, but repeated treatments can select for those cells that were able to survive initial therapy and have acquired cellular mechanisms to enhance their resistance to subsequent chemotherapy treatment. Many cellular mechanisms of drug resistance have been identified, most of which result from changes in gene and protein expression. While changes at the transcriptional level have been duly noted, it is primarily the post-transcriptional processing of pre-mRNA into mature mRNA that regulates the composition of the proteome and it is the proteome that actually regulates the cell's response to chemotherapeutic insult, inducing cell survival or death. During pre-mRNA processing, intronic non-protein-coding sequences are removed and protein-coding exons are spliced to form a continuous template for protein translation. Alternative splicing involves the differential inclusion or exclusion of exonic sequences into the mature transcript, generating different mRNA templates for protein production. This regulatory mechanism enables the potential to produce many different protein isoforms from the same gene. In this review I will explain the mechanism of alternative pre-mRNA splicing and look at some specific examples of how splicing factors, splicing factor kinases and alternative splicing of specific pre-mRNAs from genes have been shown to contribute to acquisition of the drug resistant phenotype." @default.
- W2015014748 created "2016-06-24" @default.
- W2015014748 creator A5032927381 @default.
- W2015014748 date "2012-04-01" @default.
- W2015014748 modified "2023-09-25" @default.
- W2015014748 title "Regulation of chemoresistance via alternative messenger RNA splicing" @default.
- W2015014748 cites W1505245433 @default.
- W2015014748 cites W1508200717 @default.
- W2015014748 cites W1510016 @default.
- W2015014748 cites W1531644439 @default.
- W2015014748 cites W1546538401 @default.
- W2015014748 cites W1555039620 @default.
- W2015014748 cites W1560096663 @default.
- W2015014748 cites W1755736350 @default.
- W2015014748 cites W1965828942 @default.
- W2015014748 cites W1966448711 @default.
- W2015014748 cites W1968144562 @default.
- W2015014748 cites W1972083681 @default.
- W2015014748 cites W1976954789 @default.
- W2015014748 cites W1983409515 @default.
- W2015014748 cites W1984328540 @default.
- W2015014748 cites W1987601236 @default.
- W2015014748 cites W1991377750 @default.
- W2015014748 cites W1993060456 @default.
- W2015014748 cites W1993327789 @default.
- W2015014748 cites W1994154030 @default.
- W2015014748 cites W1995048208 @default.
- W2015014748 cites W1997759940 @default.
- W2015014748 cites W1999767229 @default.
- W2015014748 cites W2001952613 @default.
- W2015014748 cites W2002073718 @default.
- W2015014748 cites W2003605043 @default.
- W2015014748 cites W2007106796 @default.
- W2015014748 cites W2010336934 @default.
- W2015014748 cites W2016762377 @default.
- W2015014748 cites W2019555382 @default.
- W2015014748 cites W2024534768 @default.
- W2015014748 cites W2030056549 @default.
- W2015014748 cites W2030837781 @default.
- W2015014748 cites W2031564845 @default.
- W2015014748 cites W2032630723 @default.
- W2015014748 cites W2035091743 @default.
- W2015014748 cites W2037195126 @default.
- W2015014748 cites W2041814912 @default.
- W2015014748 cites W2043435109 @default.
- W2015014748 cites W2043875183 @default.
- W2015014748 cites W2052983658 @default.
- W2015014748 cites W2053785878 @default.
- W2015014748 cites W2058970225 @default.
- W2015014748 cites W2059938714 @default.
- W2015014748 cites W2060826949 @default.
- W2015014748 cites W2061119775 @default.
- W2015014748 cites W2061484408 @default.
- W2015014748 cites W2062949984 @default.
- W2015014748 cites W2064065683 @default.
- W2015014748 cites W2064862565 @default.
- W2015014748 cites W2065572350 @default.
- W2015014748 cites W2068274700 @default.
- W2015014748 cites W2068816187 @default.
- W2015014748 cites W2069141227 @default.
- W2015014748 cites W2071622146 @default.
- W2015014748 cites W2072731004 @default.
- W2015014748 cites W2072958478 @default.
- W2015014748 cites W2073683821 @default.
- W2015014748 cites W2078354424 @default.
- W2015014748 cites W2078908135 @default.
- W2015014748 cites W2080457070 @default.
- W2015014748 cites W2081478041 @default.
- W2015014748 cites W2082491111 @default.
- W2015014748 cites W2082688017 @default.
- W2015014748 cites W2084390674 @default.
- W2015014748 cites W2085448417 @default.
- W2015014748 cites W2085847636 @default.
- W2015014748 cites W2089552619 @default.
- W2015014748 cites W2090972634 @default.
- W2015014748 cites W2091898769 @default.
- W2015014748 cites W2091926537 @default.
- W2015014748 cites W2092759184 @default.
- W2015014748 cites W2092859584 @default.
- W2015014748 cites W2095405582 @default.
- W2015014748 cites W2096575861 @default.
- W2015014748 cites W2097226696 @default.
- W2015014748 cites W2097843267 @default.
- W2015014748 cites W2101636442 @default.
- W2015014748 cites W2102942479 @default.
- W2015014748 cites W2105234784 @default.
- W2015014748 cites W2106704637 @default.
- W2015014748 cites W2107344403 @default.
- W2015014748 cites W2108143474 @default.
- W2015014748 cites W2108958930 @default.
- W2015014748 cites W2109936378 @default.
- W2015014748 cites W2110048188 @default.
- W2015014748 cites W2111369086 @default.
- W2015014748 cites W2115597318 @default.
- W2015014748 cites W2115803553 @default.
- W2015014748 cites W2117506397 @default.
- W2015014748 cites W2119040192 @default.
- W2015014748 cites W2119996369 @default.