FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015016370> ?p ?o ?g. }

• W2015016370 abstract "Two commercially available microneedle rollers with a needle length of 200 μm and 300 μm were selected to examine the influence of microneedle pretreatment on the percutaneous permeation of four non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen, ketoprofen, paracetamol) with different physicochemical drug characteristics in Franz-type diffusion cells. Samples of the receptor fluids were taken at predefined times over 6 hours and were analysed by UV–VIS high-performance liquid-chromatography. Histological examinations after methylene blue application were additionally performed to gather information about barrier disruption. Despite no visible pores in the stratum corneum, the microneedle pretreatment resulted in a twofold (200 μm) and threefold higher (300 μm) flux through the pretreated skin samples compared to untreated skin samples for ibuprofen and ketoprofen (LogKow > 3, melting point < 100°C). The flux of the hydrophilic compounds diclofenac and paracetamol (logKow < 1, melting point > 100°C) increased their amount by four (200 μm) to eight (300 μm), respectively. Commercially available microneedle rollers with 200–300 μm long needles enhance the drug delivery of topically applied non-steroidal anti-inflammatory drugs and represent a valuable tool for percutaneous permeation enhancement particularly for substances with poor permeability due to a hydrophilic nature and high melting points." @default.
• W2015016370 created "2016-06-24" @default.
• W2015016370 creator A5014709254 @default.
• W2015016370 creator A5075253586 @default.
• W2015016370 creator A5076313739 @default.
• W2015016370 date "2012-08-13" @default.
• W2015016370 modified "2023-10-09" @default.
• W2015016370 title "Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points" @default.
• W2015016370 cites W1591862204 @default.
• W2015016370 cites W1956967225 @default.
• W2015016370 cites W1968599942 @default.
• W2015016370 cites W1981760171 @default.
• W2015016370 cites W1982367748 @default.
• W2015016370 cites W1991575888 @default.
• W2015016370 cites W1991809645 @default.
• W2015016370 cites W1994653828 @default.
• W2015016370 cites W1996484138 @default.
• W2015016370 cites W2002230030 @default.
• W2015016370 cites W2005338850 @default.
• W2015016370 cites W2006066267 @default.
• W2015016370 cites W2013315584 @default.
• W2015016370 cites W2013545443 @default.
• W2015016370 cites W2042663944 @default.
• W2015016370 cites W2061958341 @default.
• W2015016370 cites W2070819648 @default.
• W2015016370 cites W2080888762 @default.
• W2015016370 cites W2086014349 @default.
• W2015016370 cites W2092737323 @default.
• W2015016370 cites W2093014785 @default.
• W2015016370 cites W2102742421 @default.
• W2015016370 cites W2125617328 @default.
• W2015016370 cites W2134241623 @default.
• W2015016370 cites W2147323866 @default.
• W2015016370 cites W2154115666 @default.
• W2015016370 cites W2166140642 @default.
• W2015016370 cites W2169841193 @default.
• W2015016370 cites W2235284901 @default.
• W2015016370 cites W2411608342 @default.
• W2015016370 cites W25898841 @default.
• W2015016370 cites W4250350090 @default.
• W2015016370 doi "https://doi.org/10.1186/2050-6511-13-5" @default.
• W2015016370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3506268" @default.
• W2015016370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22947102" @default.
• W2015016370 hasPublicationYear "2012" @default.
• W2015016370 type Work @default.
• W2015016370 sameAs 2015016370 @default.
• W2015016370 citedByCount "39" @default.
• W2015016370 countsByYear W20150163702013 @default.
• W2015016370 countsByYear W20150163702014 @default.
• W2015016370 countsByYear W20150163702015 @default.
• W2015016370 countsByYear W20150163702016 @default.
• W2015016370 countsByYear W20150163702017 @default.
• W2015016370 countsByYear W20150163702018 @default.
• W2015016370 countsByYear W20150163702019 @default.
• W2015016370 countsByYear W20150163702020 @default.
• W2015016370 countsByYear W20150163702021 @default.
• W2015016370 countsByYear W20150163702022 @default.
• W2015016370 countsByYear W20150163702023 @default.
• W2015016370 crossrefType "journal-article" @default.
• W2015016370 hasAuthorship W2015016370A5014709254 @default.
• W2015016370 hasAuthorship W2015016370A5075253586 @default.
• W2015016370 hasAuthorship W2015016370A5076313739 @default.
• W2015016370 hasBestOaLocation W20150163701 @default.
• W2015016370 hasConcept C142724271 @default.
• W2015016370 hasConcept C185592680 @default.
• W2015016370 hasConcept C2778201750 @default.
• W2015016370 hasConcept C2778370115 @default.
• W2015016370 hasConcept C2779826273 @default.
• W2015016370 hasConcept C2779944601 @default.
• W2015016370 hasConcept C2780035454 @default.
• W2015016370 hasConcept C2780744026 @default.
• W2015016370 hasConcept C41625074 @default.
• W2015016370 hasConcept C43617362 @default.
• W2015016370 hasConcept C50670333 @default.
• W2015016370 hasConcept C55493867 @default.
• W2015016370 hasConcept C71924100 @default.
• W2015016370 hasConcept C98274493 @default.
• W2015016370 hasConceptScore W2015016370C142724271 @default.
• W2015016370 hasConceptScore W2015016370C185592680 @default.
• W2015016370 hasConceptScore W2015016370C2778201750 @default.
• W2015016370 hasConceptScore W2015016370C2778370115 @default.
• W2015016370 hasConceptScore W2015016370C2779826273 @default.
• W2015016370 hasConceptScore W2015016370C2779944601 @default.
• W2015016370 hasConceptScore W2015016370C2780035454 @default.
• W2015016370 hasConceptScore W2015016370C2780744026 @default.
• W2015016370 hasConceptScore W2015016370C41625074 @default.
• W2015016370 hasConceptScore W2015016370C43617362 @default.
• W2015016370 hasConceptScore W2015016370C50670333 @default.
• W2015016370 hasConceptScore W2015016370C55493867 @default.
• W2015016370 hasConceptScore W2015016370C71924100 @default.
• W2015016370 hasConceptScore W2015016370C98274493 @default.
• W2015016370 hasIssue "1" @default.
• W2015016370 hasLocation W20150163701 @default.
• W2015016370 hasLocation W20150163702 @default.
• W2015016370 hasLocation W20150163703 @default.
• W2015016370 hasLocation W20150163704 @default.
• W2015016370 hasOpenAccess W2015016370 @default.
• W2015016370 hasPrimaryLocation W20150163701 @default.
• W2015016370 hasRelatedWork W1939309359 @default.
• W2015016370 hasRelatedWork W1965946257 @default.

• next