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- W2015016618 abstract "We analyzed the karyotypes of two moderately differentiated (grade 2) chondrosarcomas. Case 1 had a reciprocal translocation between chromosomes 6 and 12, t(6;12)(q25;q13) in most of the cells analyzed, as well as trisomies of chromosomes 7, 8, 11, 17, 19, and 21 and tetrasomy of chromosome 19. A reciprocal translocation involving chromosomes 12 and 19, t(12;19)(q13;q13), was noted as a highly clonal abnormality in the other case. Some cells had t(12;19) as the sole chromosome abnormality. Thus, chromosome rearrangements involving the long arm of chromosome 12 at the same region (q13) were commonly identified in the two tumors. These findings suggest that the rearrangements at 12q13 are nonrandom acquired changes that characterize a subgroup of chondrosarcomas." @default.
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- W2015016618 date "1992-05-01" @default.
- W2015016618 modified "2023-10-03" @default.
- W2015016618 title "Chromosome rearrangements at 12q13 in two cases of chondrosarcomas" @default.
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- W2015016618 doi "https://doi.org/10.1016/0165-4608(92)90230-6" @default.
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