Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015019085> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2015019085 endingPage "411" @default.
- W2015019085 startingPage "405" @default.
- W2015019085 abstract "To reveal the signaling pathway leading to oncogenecity of human cancer cells, we examined the expression and tyrosine-phosphorylation of phosphatidylinositol (PI)-3 kinase in cancer cell lines. Of the 14 cell lines examined, two poorly differentiated human gastric cancer cell lines, NUGC-4 and MKN-45, which were previously found to have aberrant elevation of tyrosine phosphorylation showed elevated levels of PI-3 kinase 85-kDa subunit expression. In these cells, tyrosine-phosphorylation and overall activity of PI-3 kinase were apparently elevated, compared with normal human fibroblasts and another well differentiated gastric cancer cell line, MKN-28. Treatment of these cells with tyrosine kinase inhibitor, genistein, strongly suppressed the PI-3 kinase activity. Furthermore, wortmannin, a potent inhibitor of PI-3 kinase, strongly suppressed the growth of these gastric cancer cells. These results suggest that the growth signaling via tyrosine phosphorylation is required for the activation of PI-3 kinase in NUGC4 and MKN-45, and that this activation plays an important role in oncogenic growth of these cells. However, these two cell lines showed different responses of PI-3 kinase to acid-treatment and tyrosine kinase inhibitors. In MKN-45, activation of PI-3 kinase appeared to be constitutive, and could be relevant to the oncogenic nature of the cell line." @default.
- W2015019085 created "2016-06-24" @default.
- W2015019085 creator A5008549101 @default.
- W2015019085 creator A5030045994 @default.
- W2015019085 creator A5061712023 @default.
- W2015019085 creator A5073313983 @default.
- W2015019085 creator A5080628024 @default.
- W2015019085 creator A5084072284 @default.
- W2015019085 creator A5086804597 @default.
- W2015019085 date "1995-02-01" @default.
- W2015019085 modified "2023-09-27" @default.
- W2015019085 title "EXPRESSION AND TYROSINE PHOSPHORYLATION OF PHOSPHATIDYL-INOSITOL-3 KINASE IN HUMAN GASTRIC-CANCER CELLS - ITS CORRELATION WITH CELL-GROWTH" @default.
- W2015019085 doi "https://doi.org/10.3892/ijo.6.2.405" @default.
- W2015019085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21556552" @default.
- W2015019085 hasPublicationYear "1995" @default.
- W2015019085 type Work @default.
- W2015019085 sameAs 2015019085 @default.
- W2015019085 citedByCount "3" @default.
- W2015019085 countsByYear W20150190852022 @default.
- W2015019085 crossrefType "journal-article" @default.
- W2015019085 hasAuthorship W2015019085A5008549101 @default.
- W2015019085 hasAuthorship W2015019085A5030045994 @default.
- W2015019085 hasAuthorship W2015019085A5061712023 @default.
- W2015019085 hasAuthorship W2015019085A5073313983 @default.
- W2015019085 hasAuthorship W2015019085A5080628024 @default.
- W2015019085 hasAuthorship W2015019085A5084072284 @default.
- W2015019085 hasAuthorship W2015019085A5086804597 @default.
- W2015019085 hasConcept C101544691 @default.
- W2015019085 hasConcept C153911025 @default.
- W2015019085 hasConcept C170493617 @default.
- W2015019085 hasConcept C180361614 @default.
- W2015019085 hasConcept C184235292 @default.
- W2015019085 hasConcept C2775960820 @default.
- W2015019085 hasConcept C2777553839 @default.
- W2015019085 hasConcept C2778308172 @default.
- W2015019085 hasConcept C2780610907 @default.
- W2015019085 hasConcept C42362537 @default.
- W2015019085 hasConcept C502942594 @default.
- W2015019085 hasConcept C51853150 @default.
- W2015019085 hasConcept C55493867 @default.
- W2015019085 hasConcept C62112901 @default.
- W2015019085 hasConcept C62478195 @default.
- W2015019085 hasConcept C82495950 @default.
- W2015019085 hasConcept C86803240 @default.
- W2015019085 hasConcept C95444343 @default.
- W2015019085 hasConcept C97029542 @default.
- W2015019085 hasConceptScore W2015019085C101544691 @default.
- W2015019085 hasConceptScore W2015019085C153911025 @default.
- W2015019085 hasConceptScore W2015019085C170493617 @default.
- W2015019085 hasConceptScore W2015019085C180361614 @default.
- W2015019085 hasConceptScore W2015019085C184235292 @default.
- W2015019085 hasConceptScore W2015019085C2775960820 @default.
- W2015019085 hasConceptScore W2015019085C2777553839 @default.
- W2015019085 hasConceptScore W2015019085C2778308172 @default.
- W2015019085 hasConceptScore W2015019085C2780610907 @default.
- W2015019085 hasConceptScore W2015019085C42362537 @default.
- W2015019085 hasConceptScore W2015019085C502942594 @default.
- W2015019085 hasConceptScore W2015019085C51853150 @default.
- W2015019085 hasConceptScore W2015019085C55493867 @default.
- W2015019085 hasConceptScore W2015019085C62112901 @default.
- W2015019085 hasConceptScore W2015019085C62478195 @default.
- W2015019085 hasConceptScore W2015019085C82495950 @default.
- W2015019085 hasConceptScore W2015019085C86803240 @default.
- W2015019085 hasConceptScore W2015019085C95444343 @default.
- W2015019085 hasConceptScore W2015019085C97029542 @default.
- W2015019085 hasIssue "2" @default.
- W2015019085 hasLocation W20150190851 @default.
- W2015019085 hasLocation W20150190852 @default.
- W2015019085 hasOpenAccess W2015019085 @default.
- W2015019085 hasPrimaryLocation W20150190851 @default.
- W2015019085 hasRelatedWork W1537076792 @default.
- W2015019085 hasRelatedWork W1896826541 @default.
- W2015019085 hasRelatedWork W1967789049 @default.
- W2015019085 hasRelatedWork W2015019085 @default.
- W2015019085 hasRelatedWork W2071649031 @default.
- W2015019085 hasRelatedWork W2102394165 @default.
- W2015019085 hasRelatedWork W2335112580 @default.
- W2015019085 hasRelatedWork W2409050692 @default.
- W2015019085 hasRelatedWork W2414739859 @default.
- W2015019085 hasRelatedWork W333592008 @default.
- W2015019085 hasVolume "6" @default.
- W2015019085 isParatext "false" @default.
- W2015019085 isRetracted "false" @default.
- W2015019085 magId "2015019085" @default.
- W2015019085 workType "article" @default.