FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015021809> ?p ?o ?g. }

• W2015021809 endingPage "1033" @default.
• W2015021809 startingPage "1027" @default.
• W2015021809 abstract "Constitutive androstane receptor (CAR) is a transcription factor to regulate the expression of several genes related to drug-metabolism. Here, we demonstrate that CAR protein accumulates during G1 in human SW480 and HepG2 cells. After the G1/S phase transition, CAR protein levels decreased, and CAR was hardly detected in cells by the late M phase. CAR expression in both cell lines was suppressed by RNA interference-mediated suppression of CDK4. Depletion of CAR by RNA interference in both cells and by hepatocyte growth factor treatment in HepG2 cells resulted in decreased MDM2 expression that led to p21 upregulation and repression of HepG2 cell growth. Thus, our results demonstrate that CAR expression is an early G1 event regulated by CDK4 that contributes to MDM2 expression; these findings suggest that CAR may influence the expression of genes involved in not only the metabolism of endogenous and exogenous substances but also in the cell proliferation." @default.
• W2015021809 created "2016-06-24" @default.
• W2015021809 creator A5007615482 @default.
• W2015021809 creator A5011827591 @default.
• W2015021809 creator A5034195657 @default.
• W2015021809 creator A5035885340 @default.
• W2015021809 creator A5048224957 @default.
• W2015021809 creator A5077704361 @default.
• W2015021809 creator A5081392938 @default.
• W2015021809 creator A5089629096 @default.
• W2015021809 date "2008-05-01" @default.
• W2015021809 modified "2023-10-14" @default.
• W2015021809 title "Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation" @default.
• W2015021809 cites W1971060960 @default.
• W2015021809 cites W1976846448 @default.
• W2015021809 cites W1982056201 @default.
• W2015021809 cites W1997933512 @default.
• W2015021809 cites W2003896111 @default.
• W2015021809 cites W2007249806 @default.
• W2015021809 cites W2017294587 @default.
• W2015021809 cites W2025215722 @default.
• W2015021809 cites W2029467685 @default.
• W2015021809 cites W2054989678 @default.
• W2015021809 cites W2055355210 @default.
• W2015021809 cites W2082979850 @default.
• W2015021809 cites W2084720330 @default.
• W2015021809 cites W2160583076 @default.
• W2015021809 cites W4362204546 @default.
• W2015021809 doi "https://doi.org/10.1016/j.bbrc.2008.02.140" @default.
• W2015021809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18331826" @default.
• W2015021809 hasPublicationYear "2008" @default.
• W2015021809 type Work @default.
• W2015021809 sameAs 2015021809 @default.
• W2015021809 citedByCount "19" @default.
• W2015021809 countsByYear W20150218092012 @default.
• W2015021809 countsByYear W20150218092013 @default.
• W2015021809 countsByYear W20150218092014 @default.
• W2015021809 countsByYear W20150218092016 @default.
• W2015021809 countsByYear W20150218092018 @default.
• W2015021809 countsByYear W20150218092019 @default.
• W2015021809 countsByYear W20150218092020 @default.
• W2015021809 crossrefType "journal-article" @default.
• W2015021809 hasAuthorship W2015021809A5007615482 @default.
• W2015021809 hasAuthorship W2015021809A5011827591 @default.
• W2015021809 hasAuthorship W2015021809A5034195657 @default.
• W2015021809 hasAuthorship W2015021809A5035885340 @default.
• W2015021809 hasAuthorship W2015021809A5048224957 @default.
• W2015021809 hasAuthorship W2015021809A5077704361 @default.
• W2015021809 hasAuthorship W2015021809A5081392938 @default.
• W2015021809 hasAuthorship W2015021809A5089629096 @default.
• W2015021809 hasConcept C104317684 @default.
• W2015021809 hasConcept C127561419 @default.
• W2015021809 hasConcept C134018914 @default.
• W2015021809 hasConcept C1491633281 @default.
• W2015021809 hasConcept C150194340 @default.
• W2015021809 hasConcept C16613235 @default.
• W2015021809 hasConcept C166703698 @default.
• W2015021809 hasConcept C186310378 @default.
• W2015021809 hasConcept C190232843 @default.
• W2015021809 hasConcept C193264327 @default.
• W2015021809 hasConcept C22615655 @default.
• W2015021809 hasConcept C29537977 @default.
• W2015021809 hasConcept C54355233 @default.
• W2015021809 hasConcept C62112901 @default.
• W2015021809 hasConcept C63932345 @default.
• W2015021809 hasConcept C67705224 @default.
• W2015021809 hasConcept C81885089 @default.
• W2015021809 hasConcept C86339819 @default.
• W2015021809 hasConcept C86803240 @default.
• W2015021809 hasConcept C95444343 @default.
• W2015021809 hasConceptScore W2015021809C104317684 @default.
• W2015021809 hasConceptScore W2015021809C127561419 @default.
• W2015021809 hasConceptScore W2015021809C134018914 @default.
• W2015021809 hasConceptScore W2015021809C1491633281 @default.
• W2015021809 hasConceptScore W2015021809C150194340 @default.
• W2015021809 hasConceptScore W2015021809C16613235 @default.
• W2015021809 hasConceptScore W2015021809C166703698 @default.
• W2015021809 hasConceptScore W2015021809C186310378 @default.
• W2015021809 hasConceptScore W2015021809C190232843 @default.
• W2015021809 hasConceptScore W2015021809C193264327 @default.
• W2015021809 hasConceptScore W2015021809C22615655 @default.
• W2015021809 hasConceptScore W2015021809C29537977 @default.
• W2015021809 hasConceptScore W2015021809C54355233 @default.
• W2015021809 hasConceptScore W2015021809C62112901 @default.
• W2015021809 hasConceptScore W2015021809C63932345 @default.
• W2015021809 hasConceptScore W2015021809C67705224 @default.
• W2015021809 hasConceptScore W2015021809C81885089 @default.
• W2015021809 hasConceptScore W2015021809C86339819 @default.
• W2015021809 hasConceptScore W2015021809C86803240 @default.
• W2015021809 hasConceptScore W2015021809C95444343 @default.
• W2015021809 hasFunder F4320320912 @default.
• W2015021809 hasIssue "4" @default.
• W2015021809 hasLocation W20150218091 @default.
• W2015021809 hasLocation W20150218092 @default.
• W2015021809 hasOpenAccess W2015021809 @default.
• W2015021809 hasPrimaryLocation W20150218091 @default.
• W2015021809 hasRelatedWork W1862697881 @default.
• W2015021809 hasRelatedWork W2024030923 @default.

• next