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- W2015027170 abstract "Please cite this paper as: Doyle and Haas (2010). The Angiogenic Response to Skeletal Muscle Overload is not Dependent on Mast Cell Activation. Microcirculation17(7), 548–556. Abstract Objective: To determine if mast cell activation in skeletal muscle contributes to overload-induced angiogenesis. Methods: Extensor digitorum longus muscle was overloaded through extirpation of the synergist muscle tibialis anterior. Muscles were removed after 1, 2, 4, 7 or 14 days, and mast cell density and degranulation were quantified by histology. The mast cell stabilizer, cromolyn, was administered acutely or chronically to test if mast cell degranulation contributes to overload-induced angiogenesis. Angiogenesis was determined by calculating capillary to muscle Fiber ratio; mast cell density and activation were quantified by histology, MMP-2 levels were assessed by gelatin zymography and VEGF protein levels were assessed by Western blotting. Results: Muscle overload increased mast cell degranulation and total mast cell number within 7 days. Mast cell stabilization with cromolyn attenuated degranulation but did not inhibit the increased mast cell density, MMP-2 activity, VEGF protein levels or the increase in capillary number following muscle overload. Conclusions: Mast cell degranulation and accumulation precede overload-induced angiogenesis, but mast cell activation is not critical to the angiogenic response following skeletal muscle overload." @default.
- W2015027170 created "2016-06-24" @default.
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- W2015027170 date "2010-07-01" @default.
- W2015027170 modified "2023-10-14" @default.
- W2015027170 title "The angiogenic response to skeletal muscle overload is not dependent on mast cell activation" @default.
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- W2015027170 doi "https://doi.org/10.1111/j.1549-8719.2010.00049.x" @default.
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