FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015031635> ?p ?o ?g. }

• W2015031635 endingPage "17308" @default.
• W2015031635 startingPage "17304" @default.
• W2015031635 abstract "The transcription factor c-myb has emerged as one of the key regulators of vertebrate hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but essentially required for definitive hematopoiesis. Using a conditional knock-out strategy, recent studies have indicated that c-myb is required for self-renewal of mouse hematopoietic stem cells. Here, we describe and characterize the c-myb mutant in a lower vertebrate, the zebrafish Danio rerio . The recessive loss-of-function allele of c-myb ( c-myb t25127 ) was identified in a collection of N -ethyl- N -nitrosourea (ENU)-induced mutants exhibiting a failure of thymopoiesis. The sequence of the mutant allele predicts a missense mutation (I181N) in the middle of the DNA recognition helix of repeat 3 of the highly conserved DNA binding domain. In keeping with the findings in the mouse, primitive hematopoiesis is not affected in the c-myb mutant fish. By contrast, definitive hematopoiesis fails, resulting in the loss of all blood cells by day 20 of development. Thus, the mutant fish lack lymphocytes and other white and red blood cells; nonetheless, they survive for 2–3 mo but show stunted growth. Because the mutant fish survive into early adulthood, it was possible to directly show that their definitive hematopoiesis is permanently extinguished. Our results, therefore, suggest that the key role of c-myb in definitive hematopoiesis is similar to that in mammals and must have become established early in vertebrate evolution." @default.
• W2015031635 created "2016-06-24" @default.
• W2015031635 creator A5001670517 @default.
• W2015031635 creator A5008785683 @default.
• W2015031635 creator A5052884340 @default.
• W2015031635 creator A5058850160 @default.
• W2015031635 creator A5072586004 @default.
• W2015031635 date "2010-09-07" @default.
• W2015031635 modified "2023-10-16" @default.
• W2015031635 title "Essential role of <i>c-myb</i> in definitive hematopoiesis is evolutionarily conserved" @default.
• W2015031635 cites W1528028656 @default.
• W2015031635 cites W1549559463 @default.
• W2015031635 cites W1969631366 @default.
• W2015031635 cites W1970900928 @default.
• W2015031635 cites W1978050358 @default.
• W2015031635 cites W1984338606 @default.
• W2015031635 cites W1990184382 @default.
• W2015031635 cites W2011096612 @default.
• W2015031635 cites W2017747777 @default.
• W2015031635 cites W2019724440 @default.
• W2015031635 cites W2025322183 @default.
• W2015031635 cites W2032417286 @default.
• W2015031635 cites W2032770593 @default.
• W2015031635 cites W2038939100 @default.
• W2015031635 cites W2039197693 @default.
• W2015031635 cites W2042531263 @default.
• W2015031635 cites W2050855482 @default.
• W2015031635 cites W2066236572 @default.
• W2015031635 cites W2084818621 @default.
• W2015031635 cites W2086551569 @default.
• W2015031635 cites W2087175242 @default.
• W2015031635 cites W2099667634 @default.
• W2015031635 cites W2100352070 @default.
• W2015031635 cites W2102457333 @default.
• W2015031635 cites W2105857125 @default.
• W2015031635 cites W2106495713 @default.
• W2015031635 cites W2112528263 @default.
• W2015031635 cites W2154699417 @default.
• W2015031635 cites W2184156621 @default.
• W2015031635 cites W2324384533 @default.
• W2015031635 cites W38643821 @default.
• W2015031635 doi "https://doi.org/10.1073/pnas.1004640107" @default.
• W2015031635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2951452" @default.
• W2015031635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20823231" @default.
• W2015031635 hasPublicationYear "2010" @default.
• W2015031635 type Work @default.
• W2015031635 sameAs 2015031635 @default.
• W2015031635 citedByCount "115" @default.
• W2015031635 countsByYear W20150316352012 @default.
• W2015031635 countsByYear W20150316352013 @default.
• W2015031635 countsByYear W20150316352014 @default.
• W2015031635 countsByYear W20150316352015 @default.
• W2015031635 countsByYear W20150316352016 @default.
• W2015031635 countsByYear W20150316352017 @default.
• W2015031635 countsByYear W20150316352018 @default.
• W2015031635 countsByYear W20150316352019 @default.
• W2015031635 countsByYear W20150316352020 @default.
• W2015031635 countsByYear W20150316352021 @default.
• W2015031635 countsByYear W20150316352022 @default.
• W2015031635 countsByYear W20150316352023 @default.
• W2015031635 crossrefType "journal-article" @default.
• W2015031635 hasAuthorship W2015031635A5001670517 @default.
• W2015031635 hasAuthorship W2015031635A5008785683 @default.
• W2015031635 hasAuthorship W2015031635A5052884340 @default.
• W2015031635 hasAuthorship W2015031635A5058850160 @default.
• W2015031635 hasAuthorship W2015031635A5072586004 @default.
• W2015031635 hasBestOaLocation W20150316352 @default.
• W2015031635 hasConcept C104317684 @default.
• W2015031635 hasConcept C109159458 @default.
• W2015031635 hasConcept C143065580 @default.
• W2015031635 hasConcept C180754005 @default.
• W2015031635 hasConcept C2776878037 @default.
• W2015031635 hasConcept C2778086970 @default.
• W2015031635 hasConcept C2780384893 @default.
• W2015031635 hasConcept C28328180 @default.
• W2015031635 hasConcept C54355233 @default.
• W2015031635 hasConcept C62794011 @default.
• W2015031635 hasConcept C86339819 @default.
• W2015031635 hasConcept C86803240 @default.
• W2015031635 hasConcept C95444343 @default.
• W2015031635 hasConceptScore W2015031635C104317684 @default.
• W2015031635 hasConceptScore W2015031635C109159458 @default.
• W2015031635 hasConceptScore W2015031635C143065580 @default.
• W2015031635 hasConceptScore W2015031635C180754005 @default.
• W2015031635 hasConceptScore W2015031635C2776878037 @default.
• W2015031635 hasConceptScore W2015031635C2778086970 @default.
• W2015031635 hasConceptScore W2015031635C2780384893 @default.
• W2015031635 hasConceptScore W2015031635C28328180 @default.
• W2015031635 hasConceptScore W2015031635C54355233 @default.
• W2015031635 hasConceptScore W2015031635C62794011 @default.
• W2015031635 hasConceptScore W2015031635C86339819 @default.
• W2015031635 hasConceptScore W2015031635C86803240 @default.
• W2015031635 hasConceptScore W2015031635C95444343 @default.
• W2015031635 hasIssue "40" @default.
• W2015031635 hasLocation W20150316351 @default.
• W2015031635 hasLocation W20150316352 @default.
• W2015031635 hasLocation W20150316353 @default.
• W2015031635 hasLocation W20150316354 @default.

• next