FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015031708> ?p ?o ?g. }

• W2015031708 endingPage "490" @default.
• W2015031708 startingPage "480" @default.
• W2015031708 abstract "The dramatically increased frequency of antibiotic resistance has led to intensive efforts towards developing new families of antibiotics. Membrane-active antibiotic peptides such as polymyxin B (PxB) hold promise as the next generation of antibiotics, since they rarely spur the evolution of resistance. At low concentrations in the membrane, PxB forms vesicle-vesicle contacts and induces lipid exchange without leakage or fusion, a phenomenon that can explain its specificity towards gram-negative bacteria by contact formation between the two phospholipids interfaces in the periplasmatic space. In this work, the interaction of PxB and the nonantibiotic derivative polymyxin B nonapeptide (PxB-NP) with monolayers of Escherichia coli membrane lipids (ECL) has been studied by thermodynamic and structural methods. PxB inserts itself into ECL monolayers as a conformation that forms intermembrane contacts with vesicles injected underneath, and induces lipid exchange when the monolayer surface pressure is set at 32 mN/m (membrane equivalence pressure) or net transfer vesicle-to-monolayer at lower surface pressures. Thermodynamic analysis of the compression isotherms of mixed monolayers indicates that PxB inserts into the monolayer with an expansion of the mean molecular area, implying that peptide and lipids form nonideal mixtures. At low concentrations, corresponding to the membrane-membrane contact form of PxB, the mixed monolayers present positive excess energy values (deltaGm(Ex)), and atomic force microscopy (AFM) imaging reveals structures of approximately 120-nm diameter that protrude from the lipid surface approximately 0.7 nm. At concentrations of PxB above 4 mol %, thermodynamic analysis gives a very high deltaGm(Ex), corresponding to nonfavorable interactions, and AFM images show round structures of 20-30 nm diameter. PxB-NP behaves in a totally different way, in agreement with its inability to form vesicle-vesicle contacts and its lack of antibiotic effect. These results are discussed in the light of the mechanism of action of PxB on the membrane of gram-negative bacteria." @default.
• W2015031708 created "2016-06-24" @default.
• W2015031708 creator A5011388276 @default.
• W2015031708 creator A5019597323 @default.
• W2015031708 creator A5033677202 @default.
• W2015031708 creator A5068260688 @default.
• W2015031708 creator A5087570303 @default.
• W2015031708 date "2004-01-01" @default.
• W2015031708 modified "2023-09-23" @default.
• W2015031708 title "Polymyxin B-lipid interactions in Langmuir-Blodgett monolayers ofEscherichia coli lipids: A thermodynamic and atomic force microscopy study" @default.
• W2015031708 cites W1975806824 @default.
• W2015031708 cites W1980595924 @default.
• W2015031708 cites W1981984118 @default.
• W2015031708 cites W1983711218 @default.
• W2015031708 cites W1985895692 @default.
• W2015031708 cites W1999935229 @default.
• W2015031708 cites W2003493354 @default.
• W2015031708 cites W2003897459 @default.
• W2015031708 cites W2004373761 @default.
• W2015031708 cites W2016775149 @default.
• W2015031708 cites W2029743627 @default.
• W2015031708 cites W2034359099 @default.
• W2015031708 cites W2034831369 @default.
• W2015031708 cites W2038306434 @default.
• W2015031708 cites W2038628700 @default.
• W2015031708 cites W2041514788 @default.
• W2015031708 cites W2044746614 @default.
• W2015031708 cites W2045110384 @default.
• W2015031708 cites W2047317522 @default.
• W2015031708 cites W2054602599 @default.
• W2015031708 cites W2075518645 @default.
• W2015031708 cites W2084037807 @default.
• W2015031708 cites W2085136523 @default.
• W2015031708 cites W2092775950 @default.
• W2015031708 cites W2093239356 @default.
• W2015031708 cites W2095363138 @default.
• W2015031708 cites W2095592651 @default.
• W2015031708 cites W2137740264 @default.
• W2015031708 cites W2140281823 @default.
• W2015031708 cites W2149623513 @default.
• W2015031708 cites W2155246554 @default.
• W2015031708 cites W2156233344 @default.
• W2015031708 cites W2175068438 @default.
• W2015031708 cites W4244732422 @default.
• W2015031708 cites W4255507877 @default.
• W2015031708 cites W794221587 @default.
• W2015031708 doi "https://doi.org/10.1002/bip.20165" @default.
• W2015031708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15526335" @default.
• W2015031708 hasPublicationYear "2004" @default.
• W2015031708 type Work @default.
• W2015031708 sameAs 2015031708 @default.
• W2015031708 citedByCount "35" @default.
• W2015031708 countsByYear W20150317082013 @default.
• W2015031708 countsByYear W20150317082014 @default.
• W2015031708 countsByYear W20150317082015 @default.
• W2015031708 countsByYear W20150317082016 @default.
• W2015031708 countsByYear W20150317082017 @default.
• W2015031708 countsByYear W20150317082018 @default.
• W2015031708 countsByYear W20150317082019 @default.
• W2015031708 countsByYear W20150317082020 @default.
• W2015031708 countsByYear W20150317082022 @default.
• W2015031708 crossrefType "journal-article" @default.
• W2015031708 hasAuthorship W2015031708A5011388276 @default.
• W2015031708 hasAuthorship W2015031708A5019597323 @default.
• W2015031708 hasAuthorship W2015031708A5033677202 @default.
• W2015031708 hasAuthorship W2015031708A5068260688 @default.
• W2015031708 hasAuthorship W2015031708A5087570303 @default.
• W2015031708 hasConcept C101677414 @default.
• W2015031708 hasConcept C104317684 @default.
• W2015031708 hasConcept C120665830 @default.
• W2015031708 hasConcept C121332964 @default.
• W2015031708 hasConcept C12554922 @default.
• W2015031708 hasConcept C130316041 @default.
• W2015031708 hasConcept C146587185 @default.
• W2015031708 hasConcept C185592680 @default.
• W2015031708 hasConcept C2778918659 @default.
• W2015031708 hasConcept C2780048723 @default.
• W2015031708 hasConcept C35068176 @default.
• W2015031708 hasConcept C39944091 @default.
• W2015031708 hasConcept C41625074 @default.
• W2015031708 hasConcept C547475151 @default.
• W2015031708 hasConcept C55493867 @default.
• W2015031708 hasConcept C57879066 @default.
• W2015031708 hasConcept C7070889 @default.
• W2015031708 hasConcept C71240020 @default.
• W2015031708 hasConcept C8010536 @default.
• W2015031708 hasConcept C86803240 @default.
• W2015031708 hasConceptScore W2015031708C101677414 @default.
• W2015031708 hasConceptScore W2015031708C104317684 @default.
• W2015031708 hasConceptScore W2015031708C120665830 @default.
• W2015031708 hasConceptScore W2015031708C121332964 @default.
• W2015031708 hasConceptScore W2015031708C12554922 @default.
• W2015031708 hasConceptScore W2015031708C130316041 @default.
• W2015031708 hasConceptScore W2015031708C146587185 @default.
• W2015031708 hasConceptScore W2015031708C185592680 @default.
• W2015031708 hasConceptScore W2015031708C2778918659 @default.
• W2015031708 hasConceptScore W2015031708C2780048723 @default.
• W2015031708 hasConceptScore W2015031708C35068176 @default.

• next