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- W2015046871 abstract "A murine keratinocyte cell-mediated mutagenesis assay was used to examine the effects of 7,8-benzoflavone (7,8-BF) on the metabolic activation of 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (BP) to mutagenic and cytotoxic metabolites. DMBA-dependent mutagenesis and cytotoxicity were strongly and coordinately inhibited by 7,8-BF in a concentration-dependent manner. BP-dependent mutagenesis was also strongly inhibited by 7,8-BF in a concentration-dependent manner; whereas BP-dependent cytotoxicity was relatively unaffected by 7,8-BF. Maximum inhibition of DMBA- and BP-dependent mutagenesis occurred when the cultured keratinocytes were treated with 7,8-BF immediately prior to the addition of BP or DMBA." @default.
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- W2015046871 date "1985-03-01" @default.
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- W2015046871 title "Differential effects of 7,8-benzoflavone on polycyclic aromatic hydrocarbon dependent mutagenesis and cytotoxicity in a keratinocyte cell-mediated mutation assay" @default.
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- W2015046871 doi "https://doi.org/10.1016/0304-3835(85)90029-1" @default.
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