FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015047896> ?p ?o ?g. }

• W2015047896 endingPage "565" @default.
• W2015047896 startingPage "557" @default.
• W2015047896 abstract "To characterize the pharmacokinetics (PK) of letrozole by noncompartmental and mixed effect modeling analysis with the exploration of effect of body compositions on the PK.The PK data of 52 normal healthy male subjects with intensive PK sampling from two separate studies were included in this analysis. Subjects were given a single oral administration of 2.5 mg letrozole (Femara®), an antiestrogenic aromatase inhibitor used to treat breast cancer. Letrozole concentrations were measured using validated high-performance liquid chromatography with tandem mass spectrometry. PK analysis was performed using NONMEM® 7.2 with first-order conditional estimation with interaction method. The association of body composition (body mass index, soft lean mass, fat free mass, body fat mass), CYP2A6 genotype (*1/*1, *1/*4), and CYP3A5 genotype (*1/*1, *1/*3, *3/*3) with the PK of letrozole were tested.A two-compartment model with mixed first and zero order absorption and first order elimination best described the letrozole concentration-time profile. Body weight and body fat mass were significant covariates for central volume of distribution and peripheral volume of distribution (Vp), respectively. In another model built using more readily available body composition measures, body mass index was also a significant covariate of Vp. However, no significant association was shown between CYP2A6 and CYP3A5 genetic polymorphism and the PK of letrozole in this study.Our results indicate that body weight, body fat mass, body mass index are associated with the volume of distribution of letrozole. This study provides an initial step toward the development of individualized letrozole therapy based on body composition." @default.
• W2015047896 created "2016-06-24" @default.
• W2015047896 creator A5003763805 @default.
• W2015047896 creator A5007426315 @default.
• W2015047896 creator A5009423272 @default.
• W2015047896 creator A5012863228 @default.
• W2015047896 creator A5028267413 @default.
• W2015047896 creator A5058329575 @default.
• W2015047896 creator A5062282462 @default.
• W2015047896 creator A5065283669 @default.
• W2015047896 creator A5065522258 @default.
• W2015047896 creator A5077838016 @default.
• W2015047896 creator A5085479819 @default.
• W2015047896 date "2012-08-01" @default.
• W2015047896 modified "2023-09-25" @default.
• W2015047896 title "The pharmacokinetics of letrozole – its association with key body mass metrics" @default.
• W2015047896 cites W1630545408 @default.
• W2015047896 cites W1894997478 @default.
• W2015047896 cites W1976694517 @default.
• W2015047896 cites W1995898825 @default.
• W2015047896 cites W2013550044 @default.
• W2015047896 cites W2017227663 @default.
• W2015047896 cites W2018005830 @default.
• W2015047896 cites W2044532076 @default.
• W2015047896 cites W2046806887 @default.
• W2015047896 cites W2050497622 @default.
• W2015047896 cites W2074119331 @default.
• W2015047896 cites W2077305666 @default.
• W2015047896 cites W2094479737 @default.
• W2015047896 cites W2134236073 @default.
• W2015047896 cites W2316773026 @default.
• W2015047896 doi "https://doi.org/10.5414/cp201709" @default.
• W2015047896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22735458" @default.
• W2015047896 hasPublicationYear "2012" @default.
• W2015047896 type Work @default.
• W2015047896 sameAs 2015047896 @default.
• W2015047896 citedByCount "9" @default.
• W2015047896 countsByYear W20150478962014 @default.
• W2015047896 countsByYear W20150478962016 @default.
• W2015047896 countsByYear W20150478962017 @default.
• W2015047896 countsByYear W20150478962018 @default.
• W2015047896 countsByYear W20150478962021 @default.
• W2015047896 crossrefType "journal-article" @default.
• W2015047896 hasAuthorship W2015047896A5003763805 @default.
• W2015047896 hasAuthorship W2015047896A5007426315 @default.
• W2015047896 hasAuthorship W2015047896A5009423272 @default.
• W2015047896 hasAuthorship W2015047896A5012863228 @default.
• W2015047896 hasAuthorship W2015047896A5028267413 @default.
• W2015047896 hasAuthorship W2015047896A5058329575 @default.
• W2015047896 hasAuthorship W2015047896A5062282462 @default.
• W2015047896 hasAuthorship W2015047896A5065283669 @default.
• W2015047896 hasAuthorship W2015047896A5065522258 @default.
• W2015047896 hasAuthorship W2015047896A5077838016 @default.
• W2015047896 hasAuthorship W2015047896A5085479819 @default.
• W2015047896 hasConcept C109650736 @default.
• W2015047896 hasConcept C112705442 @default.
• W2015047896 hasConcept C120863210 @default.
• W2015047896 hasConcept C121608353 @default.
• W2015047896 hasConcept C126322002 @default.
• W2015047896 hasConcept C134018914 @default.
• W2015047896 hasConcept C139254425 @default.
• W2015047896 hasConcept C147583825 @default.
• W2015047896 hasConcept C185592680 @default.
• W2015047896 hasConcept C196013638 @default.
• W2015047896 hasConcept C2776166826 @default.
• W2015047896 hasConcept C2776239304 @default.
• W2015047896 hasConcept C2778504769 @default.
• W2015047896 hasConcept C2778812593 @default.
• W2015047896 hasConcept C2780221984 @default.
• W2015047896 hasConcept C526171541 @default.
• W2015047896 hasConcept C530470458 @default.
• W2015047896 hasConcept C62231903 @default.
• W2015047896 hasConcept C71924100 @default.
• W2015047896 hasConcept C98274493 @default.
• W2015047896 hasConceptScore W2015047896C109650736 @default.
• W2015047896 hasConceptScore W2015047896C112705442 @default.
• W2015047896 hasConceptScore W2015047896C120863210 @default.
• W2015047896 hasConceptScore W2015047896C121608353 @default.
• W2015047896 hasConceptScore W2015047896C126322002 @default.
• W2015047896 hasConceptScore W2015047896C134018914 @default.
• W2015047896 hasConceptScore W2015047896C139254425 @default.
• W2015047896 hasConceptScore W2015047896C147583825 @default.
• W2015047896 hasConceptScore W2015047896C185592680 @default.
• W2015047896 hasConceptScore W2015047896C196013638 @default.
• W2015047896 hasConceptScore W2015047896C2776166826 @default.
• W2015047896 hasConceptScore W2015047896C2776239304 @default.
• W2015047896 hasConceptScore W2015047896C2778504769 @default.
• W2015047896 hasConceptScore W2015047896C2778812593 @default.
• W2015047896 hasConceptScore W2015047896C2780221984 @default.
• W2015047896 hasConceptScore W2015047896C526171541 @default.
• W2015047896 hasConceptScore W2015047896C530470458 @default.
• W2015047896 hasConceptScore W2015047896C62231903 @default.
• W2015047896 hasConceptScore W2015047896C71924100 @default.
• W2015047896 hasConceptScore W2015047896C98274493 @default.
• W2015047896 hasIssue "08" @default.
• W2015047896 hasLocation W20150478961 @default.
• W2015047896 hasLocation W20150478962 @default.
• W2015047896 hasOpenAccess W2015047896 @default.

• next