FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015064826> ?p ?o ?g. }

• W2015064826 endingPage "122" @default.
• W2015064826 startingPage "112" @default.
• W2015064826 abstract "Hyperoxia (HP) exposure inducts reactive oxygen species (ROS) in the lungs that may result in lung injury, including alveolar epithelial and endothelial cells. Lactate dehydrogenase (LDH) activity relates to glycolysis, whereas glutathione peroxidase (Gpx) activity relies on the pentose phosphate pathway (PPP). The purpose of this study was to examine early ROS-induced alveolar pathological changes in relation to the activity of glutathione peroxidase (GPx) and lactate dehydrogenase (LDH) activity. Twenty adult male rats, matched with age and body weight, were randomly assigned to two groups, control and experimental. The experimental group was exposed to hyperoxia for 24 h. Ultrastructure examination showed degenerated pneumocyte type I, containing swollen mitochondria associated with dilated rough endoplasmic reticulum, and was projecting into the alveolar lumen. Pneumocyte II showed mitochondria swelling and hyperplasia and was desquamated in structure, depleted in surfactant, and falling into the alveolar lumen. Pulmonary capillary showed distention without observed damage in the endothelial layer. Following HP, the average (±) free radical (FR) production increased significantly (p<.05) from the baseline control of 181.20±30.06 to 260.30±68.10 (Carr U) and average (±SD) GPx activity also increased significantly (p<.05) from the baseline control of 8178.30±2402.62 to 19,589.50±2392.44 (U/L), whereas average (±SD) LDH activity decreased significantly (p<.05) from baseline control of 194.11±75.52 to 42.68±11.41 (U/L), which demonstrated slowing down of glycolysis. Based on these results it can be concluded that exposure to high inspired oxygen inducted the buildup of mitochondria-driven ROS that was related to early injury in the alveolar epithelium without obvious endothelium injury." @default.
• W2015064826 created "2016-06-24" @default.
• W2015064826 creator A5016527090 @default.
• W2015064826 creator A5027931638 @default.
• W2015064826 creator A5062352333 @default.
• W2015064826 date "2009-01-01" @default.
• W2015064826 modified "2023-09-28" @default.
• W2015064826 title "Effect of Hyperoxia on the Ultrastructural Pathology of Alveolar Epithelium in Relation to Glutathione Peroxidase, Lactate Dehydrogenase Activities, and Free Radical Production in Rats,Rattus norvigicus" @default.
• W2015064826 cites W1565127991 @default.
• W2015064826 cites W1925799544 @default.
• W2015064826 cites W1940436875 @default.
• W2015064826 cites W1963639235 @default.
• W2015064826 cites W1975333034 @default.
• W2015064826 cites W1987993391 @default.
• W2015064826 cites W2011250019 @default.
• W2015064826 cites W2015145167 @default.
• W2015064826 cites W2016307666 @default.
• W2015064826 cites W2028855217 @default.
• W2015064826 cites W2034960012 @default.
• W2015064826 cites W2041794488 @default.
• W2015064826 cites W2043932858 @default.
• W2015064826 cites W2048040489 @default.
• W2015064826 cites W2049109743 @default.
• W2015064826 cites W2059545411 @default.
• W2015064826 cites W2061488539 @default.
• W2015064826 cites W2069498955 @default.
• W2015064826 cites W2070017721 @default.
• W2015064826 cites W2071468558 @default.
• W2015064826 cites W2072839106 @default.
• W2015064826 cites W2073329101 @default.
• W2015064826 cites W2077352007 @default.
• W2015064826 cites W2079380240 @default.
• W2015064826 cites W2090372772 @default.
• W2015064826 cites W2092922043 @default.
• W2015064826 cites W2095517841 @default.
• W2015064826 cites W2100582080 @default.
• W2015064826 cites W2105491135 @default.
• W2015064826 cites W2109129636 @default.
• W2015064826 cites W2112680688 @default.
• W2015064826 cites W2115812377 @default.
• W2015064826 cites W2120659958 @default.
• W2015064826 cites W2124542794 @default.
• W2015064826 cites W2133254979 @default.
• W2015064826 cites W2144749256 @default.
• W2015064826 cites W2147415413 @default.
• W2015064826 cites W2148916824 @default.
• W2015064826 cites W2152480018 @default.
• W2015064826 cites W2157597415 @default.
• W2015064826 cites W2167469249 @default.
• W2015064826 cites W2169117498 @default.
• W2015064826 cites W2170418712 @default.
• W2015064826 cites W2171285875 @default.
• W2015064826 cites W2211716140 @default.
• W2015064826 cites W2308938068 @default.
• W2015064826 cites W2319396397 @default.
• W2015064826 cites W2322458195 @default.
• W2015064826 cites W243564831 @default.
• W2015064826 cites W38819264 @default.
• W2015064826 doi "https://doi.org/10.1080/01913120902889179" @default.
• W2015064826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19479651" @default.
• W2015064826 hasPublicationYear "2009" @default.
• W2015064826 type Work @default.
• W2015064826 sameAs 2015064826 @default.
• W2015064826 citedByCount "9" @default.
• W2015064826 countsByYear W20150648262012 @default.
• W2015064826 countsByYear W20150648262013 @default.
• W2015064826 countsByYear W20150648262015 @default.
• W2015064826 crossrefType "journal-article" @default.
• W2015064826 hasAuthorship W2015064826A5016527090 @default.
• W2015064826 hasAuthorship W2015064826A5027931638 @default.
• W2015064826 hasAuthorship W2015064826A5062352333 @default.
• W2015064826 hasConcept C126322002 @default.
• W2015064826 hasConcept C134018914 @default.
• W2015064826 hasConcept C16685009 @default.
• W2015064826 hasConcept C181199279 @default.
• W2015064826 hasConcept C185592680 @default.
• W2015064826 hasConcept C20251656 @default.
• W2015064826 hasConcept C2775838275 @default.
• W2015064826 hasConcept C2777318727 @default.
• W2015064826 hasConcept C2777714996 @default.
• W2015064826 hasConcept C2778004101 @default.
• W2015064826 hasConcept C2778175917 @default.
• W2015064826 hasConcept C2778760513 @default.
• W2015064826 hasConcept C2780672939 @default.
• W2015064826 hasConcept C28859421 @default.
• W2015064826 hasConcept C3409486 @default.
• W2015064826 hasConcept C55493867 @default.
• W2015064826 hasConcept C62231903 @default.
• W2015064826 hasConcept C71924100 @default.
• W2015064826 hasConcept C86803240 @default.
• W2015064826 hasConceptScore W2015064826C126322002 @default.
• W2015064826 hasConceptScore W2015064826C134018914 @default.
• W2015064826 hasConceptScore W2015064826C16685009 @default.
• W2015064826 hasConceptScore W2015064826C181199279 @default.
• W2015064826 hasConceptScore W2015064826C185592680 @default.
• W2015064826 hasConceptScore W2015064826C20251656 @default.
• W2015064826 hasConceptScore W2015064826C2775838275 @default.
• W2015064826 hasConceptScore W2015064826C2777318727 @default.

• next