FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015074551> ?p ?o ?g. }

• W2015074551 endingPage "573" @default.
• W2015074551 startingPage "568" @default.
• W2015074551 abstract "Deoxyuridine triphosphatase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate thus preventing the incorporation of uracil into replicating DNA. Previous studies of several virus models have suggested that viral dUTPases may be required for virus replication in resting cells whereas in proliferating cells cellular dUTPase may substitute for a mutant viral protein. Using monoclonal antibodies and immunohistochemistry, Epstein-Barr virus-associated non-neoplastic and neoplastic diseases were studied for the expression of viral and human dUTPases. Oral hairy leukoplakia, an AIDS-associated lesion of the tongue, is known to support EBV replication in the upper epithelial cell layers. In agreement with this, strong focal expression of EBV dUTPase was detected in the upper epithelial cell layers of oral hairy leukoplakia whereas expression of human dUTPase was confined to the basal proliferative cell compartment. Furthermore, in infectious mononucleosis tonsils, rare scattered small lymphoid cells expressed EBV dUTPase, consistent with the expression pattern of other EBV lytic cycle antigens. These findings are in agreement with the notion that EBV replicates in resting cells. Three EBV-associated tumours, Hodgkin lymphoma, Burkitt lymphoma and nasopharyngeal carcinoma, lacked detectable expression of EBV dUTPase, in agreement with the notion that EBV infection is largely latent in these tumours. By contrast, expression of human dUTPase was observed regularly in these tumours. These results suggest that EBV dUTPase may be a suitable target for anti-viral therapy and that inhibitors of human dUTPase should prove useful for the treatment of human tumours, including EBV-associated cancers." @default.
• W2015074551 created "2016-06-24" @default.
• W2015074551 creator A5012470161 @default.
• W2015074551 creator A5016523508 @default.
• W2015074551 creator A5021006948 @default.
• W2015074551 creator A5029505615 @default.
• W2015074551 creator A5065576952 @default.
• W2015074551 date "2002-10-10" @default.
• W2015074551 modified "2023-09-25" @default.
• W2015074551 title "Expression of viral and human dUTPase in Epstein-Barr virus-associated diseases" @default.
• W2015074551 cites W142012039 @default.
• W2015074551 cites W1489865648 @default.
• W2015074551 cites W1495420648 @default.
• W2015074551 cites W1795128040 @default.
• W2015074551 cites W1812947354 @default.
• W2015074551 cites W1948895965 @default.
• W2015074551 cites W1968179681 @default.
• W2015074551 cites W1996168666 @default.
• W2015074551 cites W2001679506 @default.
• W2015074551 cites W2018366500 @default.
• W2015074551 cites W2022958876 @default.
• W2015074551 cites W2036746359 @default.
• W2015074551 cites W2042467869 @default.
• W2015074551 cites W2055166751 @default.
• W2015074551 cites W2076596370 @default.
• W2015074551 cites W2076665646 @default.
• W2015074551 cites W2077908003 @default.
• W2015074551 cites W2089097686 @default.
• W2015074551 cites W2122800938 @default.
• W2015074551 cites W2144860807 @default.
• W2015074551 cites W2145675421 @default.
• W2015074551 cites W2154536753 @default.
• W2015074551 cites W2169857558 @default.
• W2015074551 cites W2169975488 @default.
• W2015074551 doi "https://doi.org/10.1002/jmv.10234" @default.
• W2015074551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12376965" @default.
• W2015074551 hasPublicationYear "2002" @default.
• W2015074551 type Work @default.
• W2015074551 sameAs 2015074551 @default.
• W2015074551 citedByCount "19" @default.
• W2015074551 countsByYear W20150745512012 @default.
• W2015074551 countsByYear W20150745512013 @default.
• W2015074551 countsByYear W20150745512014 @default.
• W2015074551 countsByYear W20150745512018 @default.
• W2015074551 countsByYear W20150745512022 @default.
• W2015074551 crossrefType "journal-article" @default.
• W2015074551 hasAuthorship W2015074551A5012470161 @default.
• W2015074551 hasAuthorship W2015074551A5016523508 @default.
• W2015074551 hasAuthorship W2015074551A5021006948 @default.
• W2015074551 hasAuthorship W2015074551A5029505615 @default.
• W2015074551 hasAuthorship W2015074551A5065576952 @default.
• W2015074551 hasConcept C126322002 @default.
• W2015074551 hasConcept C140704245 @default.
• W2015074551 hasConcept C159047783 @default.
• W2015074551 hasConcept C182615771 @default.
• W2015074551 hasConcept C203014093 @default.
• W2015074551 hasConcept C2522874641 @default.
• W2015074551 hasConcept C2778997737 @default.
• W2015074551 hasConcept C2779338263 @default.
• W2015074551 hasConcept C2780879997 @default.
• W2015074551 hasConcept C2781375147 @default.
• W2015074551 hasConcept C502942594 @default.
• W2015074551 hasConcept C509974204 @default.
• W2015074551 hasConcept C71924100 @default.
• W2015074551 hasConcept C86803240 @default.
• W2015074551 hasConceptScore W2015074551C126322002 @default.
• W2015074551 hasConceptScore W2015074551C140704245 @default.
• W2015074551 hasConceptScore W2015074551C159047783 @default.
• W2015074551 hasConceptScore W2015074551C182615771 @default.
• W2015074551 hasConceptScore W2015074551C203014093 @default.
• W2015074551 hasConceptScore W2015074551C2522874641 @default.
• W2015074551 hasConceptScore W2015074551C2778997737 @default.
• W2015074551 hasConceptScore W2015074551C2779338263 @default.
• W2015074551 hasConceptScore W2015074551C2780879997 @default.
• W2015074551 hasConceptScore W2015074551C2781375147 @default.
• W2015074551 hasConceptScore W2015074551C502942594 @default.
• W2015074551 hasConceptScore W2015074551C509974204 @default.
• W2015074551 hasConceptScore W2015074551C71924100 @default.
• W2015074551 hasConceptScore W2015074551C86803240 @default.
• W2015074551 hasFunder F4320320879 @default.
• W2015074551 hasIssue "4" @default.
• W2015074551 hasLocation W20150745511 @default.
• W2015074551 hasLocation W20150745512 @default.
• W2015074551 hasOpenAccess W2015074551 @default.
• W2015074551 hasPrimaryLocation W20150745511 @default.
• W2015074551 hasRelatedWork W2010351158 @default.
• W2015074551 hasRelatedWork W2119658998 @default.
• W2015074551 hasRelatedWork W2153329275 @default.
• W2015074551 hasRelatedWork W2400907083 @default.
• W2015074551 hasRelatedWork W2416019078 @default.
• W2015074551 hasRelatedWork W2539117947 @default.
• W2015074551 hasRelatedWork W2569059767 @default.
• W2015074551 hasRelatedWork W2770380843 @default.
• W2015074551 hasRelatedWork W3080799775 @default.
• W2015074551 hasRelatedWork W42091549 @default.
• W2015074551 hasVolume "68" @default.
• W2015074551 isParatext "false" @default.
• W2015074551 isRetracted "false" @default.

• next